CHAIR an antigen-resolved antibody-reactome resource for healthy adult immune aging
- 1Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine, Ministry of Education, Tong Ren Hospital, Shanghai Jiao Tong University, Shangha
Abstract
Antigen-recognition histories accumulate across adult life, but existing human aging resources largely emphasize host-state measurements rather than antigen-resolved humoral memory. We present CHAIR, the Chinese Healthy Aging Immune Resource, which integrates self-antigen, human virome and toxin/virulence-factor PhIP-seq with routine clinical measurements and T/B/NK phenotyping in clinically screened adults aged 20-94 years. The resource framework includes 1,008 unique PhIP-seq samples, 995 clinical records, 977 T/B/NK records and 853 participants with all three layers. Across modeled spaces comprising 23,584 self-antigen targets, 210 virome targets and 1,258 virulence-factor source targets, most measured antibody-reactivity architecture was consistent with broad preservation within domains, whereas age- and sex-associated signals were concentrated in focal targets and modules. Together, CHAIR provides a traceable, antigen-resolved reference framework based on clinically screened adults for investigating focal humoral remodeling across healthy adult aging.
Related
- Co-administration of Staphylococcus aures Fibronectin Binding Protein A N1-3 region and Lipoteichoic acid antigen mixture enhance antibody response in BALB/c mice
- Sequence-only antigen context improves modeling of antibody hypervariable regions
- CIR-DDG: backbone-agnostic residual correction of antibody-antigen affinity changes with explicit cross-chain geometry
- BCell-Epitope-Prediction: A local, reproducible pipeline for multi-epitope vaccine design: integration and structural validation against a panel of PDB antigen-antibody complexes
- Antibody-Antigen Affinity Prediction with Chain-Aware Protein Language Modeling
BibTeX
@misc{sundell2026chair,
title = {{CHAIR an antigen-resolved antibody-reactome resource for healthy adult immune aging}},
author = {G. N. Sundell and M. Chen and Z. Sha and X. Sun and J. Yao and J. Liu and C. Hu and H. Xu and J. Dai and H. Qi and M. Ma and J. Wu and Y. Li and S. Guo and J. Lin and H. Sheng and S.-C. Tao},
howpublished = {bioRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.29.755197},
url = {https://www.biorxiv.org/content/10.64898/2026.09.29.755197v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - CHAIR an antigen-resolved antibody-reactome resource for healthy adult immune aging
AU - G. N. Sundell
AU - M. Chen
AU - Z. Sha
AU - X. Sun
AU - J. Yao
AU - J. Liu
AU - C. Hu
AU - H. Xu
AU - J. Dai
AU - H. Qi
AU - M. Ma
AU - J. Wu
AU - Y. Li
AU - S. Guo
AU - J. Lin
AU - H. Sheng
AU - S.-C. Tao
PY - 2026
DA - 2026/09/29
PB - bioRxiv
DO - 10.64898/2026.09.29.755197
UR - https://www.biorxiv.org/content/10.64898/2026.09.29.755197v1
AB - Antigen-recognition histories accumulate across adult life, but existing human aging resources largely emphasize host-state measurements rather than antigen-resolved humoral memory. We present CHAIR, the Chinese Healthy Aging Immune Resource, which integrates self-antigen, human virome and toxin/virulence-factor PhIP-seq with routine clinical measurements and T/B/NK phenotyping in clinically screened adults aged 20-94 years. The resource framework includes 1,008 unique PhIP-seq samples, 995 clinical records, 977 T/B/NK records and 853 participants with all three layers. Across modeled spaces comprising 23,584 self-antigen targets, 210 virome targets and 1,258 virulence-factor source targets, most measured antibody-reactivity architecture was consistent with broad preservation within domains, whereas age- and sex-associated signals were concentrated in focal targets and modules. Together, CHAIR provides a traceable, antigen-resolved reference framework based on clinically screened adults for investigating focal humoral remodeling across healthy adult aging.
ER -