Economic Impact of Healthcare Associated Infections (HAI) Prevention Across Surgical Units
Abstract
Background and Aim: Healthcare-associated infections (HAIs) represent a significant burden on healthcare systems, leading to increased morbidity, prolonged hospital stays, and elevated costs. Surgical site infections (SSIs) are among the most prevalent HAIs, often surpassing the cost of the surgical procedures themselves. This study aims to evaluate the economic impact of a preventive intervention designed to reduce SSIs prevalence at the Fondazione Policlinico A. Gemelli IRCCS.
Methods: A point prevalence survey (PPS) was conducted in the months of June 2023 and 2024 at the Fondazione Policlinico Agostino Gemelli IRCSS, following the European Centre for Disease Prevention and Control (ECDC) protocol. The study analyzed data from hospitalized surgical patients, comparing SSI prevalence before and after the implementation of a preventive intervention (bundle approach). An economic evaluation was performed using a budget impact model, estimating cost savings from the reduction in SSI cases. Sensitivity analysis was conducted to assess variations in intervention effectiveness.
Results: The prevalence of SSIs decreased from 2.5% in 2023 to 1.4% in 2024, representing a 44% reduction. The estimated number of SSI cases dropped from 2,287 to 1,281, resulting in a cost reduction of approximately €31.6 million in direct healthcare expenses. The projected economic benefits for 2025 and 2026 suggest further savings if the downward trend continues.
Discussion: The findings indicate that targeted preventive measures significantly reduce SSI prevalence and associated costs. The reduction rate exceeds previously reported figures in the literature, emphasizing the effectiveness of the intervention. While the study relies on point prevalence data, the results advocate for broader implementation of similar prevention strategies in hospital settings to enhance patient safety and economic sustainability
Key messages: • A simple prevention bundle cut surgical infections nearly in half—proving cost-saving and life-saving go hand in hand
• Targeted preventive measures reduced SSI prevalence by 44%, saving €31.6 million in direct healthcare costs.
Related
- Surgical Antimicrobial Prophylaxis: Clinical and Economic Impacts on Surgical Site Infection Prevention and Healthcare System Sustainability.
- Development and content validation of a risk-stratified nursing intervention programme for the prevention of healthcare-associated infections
- Extending prophylactic antimicrobial use beyond 48 h postoperatively fails to reduce surgical site infections and other healthcare-associated infections in patients undergoing colorectal resection: a Propensity Score Matching study
- Registered trials for healthcare-associated infections prevention in intensive care units, 2000-2025
- Prevalence, Etiology, and Clinical Outcomes of Healthcare-Associated Infections in a Tertiary Pediatric Hospital.
BibTeX
@article{cacciuttolo2026economic,
title = {{Economic Impact of Healthcare Associated Infections (HAI) Prevention Across Surgical Units}},
author = {M G Cacciuttolo and M L Specchia and M Bonacquisti and L Russo and P Laurenti},
journal = {The European Journal of Public Health},
year = {2026},
month = oct,
doi = {10.1093/eurpub/ckag169.1632},
url = {https://doi.org/10.1093/eurpub/ckag169.1632},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Economic Impact of Healthcare Associated Infections (HAI) Prevention Across Surgical Units
AU - M G Cacciuttolo
AU - M L Specchia
AU - M Bonacquisti
AU - L Russo
AU - P Laurenti
PY - 2026
DA - 2026/10/01
JO - The European Journal of Public Health
DO - 10.1093/eurpub/ckag169.1632
UR - https://doi.org/10.1093/eurpub/ckag169.1632
AB - Background and Aim: Healthcare-associated infections (HAIs) represent a significant burden on healthcare systems, leading to increased morbidity, prolonged hospital stays, and elevated costs. Surgical site infections (SSIs) are among the most prevalent HAIs, often surpassing the cost of the surgical procedures themselves. This study aims to evaluate the economic impact of a preventive intervention designed to reduce SSIs prevalence at the Fondazione Policlinico A. Gemelli IRCCS. Methods: A point prevalence survey (PPS) was conducted in the months of June 2023 and 2024 at the Fondazione Policlinico Agostino Gemelli IRCSS, following the European Centre for Disease Prevention and Control (ECDC) protocol. The study analyzed data from hospitalized surgical patients, comparing SSI prevalence before and after the implementation of a preventive intervention (bundle approach). An economic evaluation was performed using a budget impact model, estimating cost savings from the reduction in SSI cases. Sensitivity analysis was conducted to assess variations in intervention effectiveness. Results: The prevalence of SSIs decreased from 2.5% in 2023 to 1.4% in 2024, representing a 44% reduction. The estimated number of SSI cases dropped from 2,287 to 1,281, resulting in a cost reduction of approximately €31.6 million in direct healthcare expenses. The projected economic benefits for 2025 and 2026 suggest further savings if the downward trend continues. Discussion: The findings indicate that targeted preventive measures significantly reduce SSI prevalence and associated costs. The reduction rate exceeds previously reported figures in the literature, emphasizing the effectiveness of the intervention. While the study relies on point prevalence data, the results advocate for broader implementation of similar prevention strategies in hospital settings to enhance patient safety and economic sustainability Key messages: • A simple prevention bundle cut surgical infections nearly in half—proving cost-saving and life-saving go hand in hand • Targeted preventive measures reduced SSI prevalence by 44%, saving €31.6 million in direct healthcare costs.
SN - 1101-1262
SN - 1464-360X
ER -