Efficacy of nutraceuticals as adjunctive therapies in autoimmune diseases: A systematic review of clinical trials.
- 1Research Center in Nutrition and Public Health, School of Public Health and Nutrition, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Abstract
Introduction
Autoimmune diseases are characterized by a dysregulation of the immune system, resulting in chronic inflammation and tissue damage. Although immunosuppressive therapies have advanced, their limited efficacy and the adverse effects associated with long-term use restrict their clinical utility, highlighting the need for alternative treatments. This study aimed to synthesize current evidence on the efficacy of nutraceutical interventions for these disorders.Methods
A comprehensive search was conducted on PubMed, Embase, and ClinicalTrials.gov to identify studies published between 2010 and 2025 evaluating nutraceutical supplementation in patients with autoimmune diseases. Study selection and data extraction were performed according to predefined inclusion criteria.Results
Thirty clinical trials involved 2,107 participants with rheumatoid arthritis, psoriasis, multiple sclerosis, systemic lupus erythematosus, or Hashimoto's thyroiditis. Interventions included polyphenols, vitamins, minerals, omega-3 fatty acids, and probiotics, administered over 4 to 48 weeks, with sample sizes ranging from 24 to 351 participants. The studies demonstrated anti-inflammatory and immunoregulatory effects, as well as improvements in disease activity and clinical symptoms following supplementation with curcumin, probiotics, vitamin D, omega-3 fatty acids, baicalin, resveratrol, and quercetin. Additionally, reductions in autoantibody levels were observed after supplementation with curcumin, selenium, and genistein.Conclusion
The available evidence suggests that these nutraceuticals are emerging as candidates with therapeutic potential for integration as adjunctive therapies in the management of autoimmune diseases.
Related
- Comparative Efficacy and Safety of Systemic Immunomodulatory Therapies for Non‐Infectious Uveitis: A Systematic Review With Pairwise and Network Meta‐Analyses
- Efficacy of combined therapies on degenerative joint disease of the temporomandibular joint: A systematic review and meta-analysis
- Comparative efficacy and safety of targeted disease-modifying therapies in adults with primary IgA nephropathy: a systematic review and network meta-analysis
- Clinical efficacy and biological rationale of adjunctive distrept-enzymes H46A streptokinase-streptodornase therapy in gynecology: a systematic review with quantitative synthesis
- Efficacy and Safety of Adjunctive Corticosteroids in Children With Kawasaki Disease: A Systematic Review and Meta-Analysis of Randomized Trials
BibTeX
@article{iglesias2026efficacy,
title = {{Efficacy of nutraceuticals as adjunctive therapies in autoimmune diseases: A systematic review of clinical trials.}},
author = {Jennifer Carolina Flores Iglesias and Luis Fernando Méndez López},
journal = {BioImpacts : BI},
year = {2026},
month = aug,
doi = {10.34172/bi.33535},
url = {https://europepmc.org/article/MED/42898270},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Efficacy of nutraceuticals as adjunctive therapies in autoimmune diseases: A systematic review of clinical trials.
AU - Jennifer Carolina Flores Iglesias
AU - Luis Fernando Méndez López
PY - 2026
DA - 2026/08/16
JO - BioImpacts : BI
DO - 10.34172/bi.33535
UR - https://europepmc.org/article/MED/42898270
AB - Introduction Autoimmune diseases are characterized by a dysregulation of the immune system, resulting in chronic inflammation and tissue damage. Although immunosuppressive therapies have advanced, their limited efficacy and the adverse effects associated with long-term use restrict their clinical utility, highlighting the need for alternative treatments. This study aimed to synthesize current evidence on the efficacy of nutraceutical interventions for these disorders.Methods A comprehensive search was conducted on PubMed, Embase, and ClinicalTrials.gov to identify studies published between 2010 and 2025 evaluating nutraceutical supplementation in patients with autoimmune diseases. Study selection and data extraction were performed according to predefined inclusion criteria.Results Thirty clinical trials involved 2,107 participants with rheumatoid arthritis, psoriasis, multiple sclerosis, systemic lupus erythematosus, or Hashimoto's thyroiditis. Interventions included polyphenols, vitamins, minerals, omega-3 fatty acids, and probiotics, administered over 4 to 48 weeks, with sample sizes ranging from 24 to 351 participants. The studies demonstrated anti-inflammatory and immunoregulatory effects, as well as improvements in disease activity and clinical symptoms following supplementation with curcumin, probiotics, vitamin D, omega-3 fatty acids, baicalin, resveratrol, and quercetin. Additionally, reductions in autoantibody levels were observed after supplementation with curcumin, selenium, and genistein.Conclusion The available evidence suggests that these nutraceuticals are emerging as candidates with therapeutic potential for integration as adjunctive therapies in the management of autoimmune diseases.
SN - 2228-5652
SN - 2228-5660
ER -