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Peer-reviewedCC BY-NC-ND 4.0Communications Medicine

Exploiting iron metabolism in Ewing sarcoma

  • Colin M. Hayes
  • Emily R. Theisen
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Abstract

Ewing sarcoma is an aggressive bone cancer of children and young adults. Survivors face long-term complications from intensive chemotherapy and outcomes remain stubbornly poor for patients with metastases. There is an urgent need for improved treatments. Emerging evidence suggests Ewing sarcoma is particularly sensitive to perturbed iron homeostasis. As iron contributes to many critical processes, there are multiple mechanisms to disrupt iron metabolism. Several pre-clinical studies exploiting altered iron homeostasis in Ewing sarcoma report encouraging results. This review summarizes unique features of and ways to target iron metabolism in Ewing sarcoma, and the translational potential for these therapeutic strategies.

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Cite

BibTeXRIS
BibTeX
@article{hayes2026exploiting,
  title = {{Exploiting iron metabolism in Ewing sarcoma}},
  author = {Colin M. Hayes and Emily R. Theisen},
  journal = {Communications Medicine},
  year = {2026},
  month = oct,
  doi = {10.1038/s43856-026-01954-3},
  url = {https://www.nature.com/articles/s43856-026-01954-3},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Exploiting iron metabolism in Ewing sarcoma
AU  - Colin M. Hayes
AU  - Emily R. Theisen
PY  - 2026
DA  - 2026/10/28
JO  - Communications Medicine
DO  - 10.1038/s43856-026-01954-3
UR  - https://www.nature.com/articles/s43856-026-01954-3
AB  - Ewing sarcoma is an aggressive bone cancer of children and young adults. Survivors face long-term complications from intensive chemotherapy and outcomes remain stubbornly poor for patients with metastases. There is an urgent need for improved treatments. Emerging evidence suggests Ewing sarcoma is particularly sensitive to perturbed iron homeostasis. As iron contributes to many critical processes, there are multiple mechanisms to disrupt iron metabolism. Several pre-clinical studies exploiting altered iron homeostasis in Ewing sarcoma report encouraging results. This review summarizes unique features of and ways to target iron metabolism in Ewing sarcoma, and the translational potential for these therapeutic strategies.
SN  - 2730-664X
ER  -