Regional Heterogeneity of Sensorimotor BOLD Lateralization During Unilateral Hand Movement
Abstract
Unilateral hand movement engages contralateral sensorimotor cortex, but the balance of contralateral and ipsilateral responses can differ across regions. We quantified regional blood oxygen level-dependent lateralization in 20 CoSpine participants and compared corresponding endpoints in 100 unrelated Human Connectome Project participants. Bilateral Brainnetome parcels represented primary motor, primary somatosensory, dorsal premotor, and ventral premotor regions. Lateralization averaged the contralateral-minus-ipsilateral activation contrast across hands. CoSpine analyses used refitted activation models without physiological-recording regressors, following input qualification and correction of anatomical-mask mapping. Analyses retained five within-participant regional contrasts and a covariance-aware bootstrap sensitivity test. CoSpine composite lateralization averaged 28.059 contrast-of-parameter-estimate units (95% confidence interval 23.718–32.551). The covariance-aware analysis supported regional heterogeneity (p < 0.001). Primary motor and somatosensory regions had the largest mean lateralization, dorsal premotor cortex an intermediate mean, and ventral premotor cortex a mean near zero. Four regional contrasts survived Holm correction; the primary motor–somatosensory difference was 3.653 units (95% confidence interval − 4.559 to 13.112; adjusted p = 0.462). The independent cohort showed a similar regional pattern, with a supported primary motor–somatosensory difference and weak positive ventral premotor lateralization. These results characterize regional variation in hemispheric response balance beyond the general observation of contralateral activation. The shared atlas-level pattern across distinct motor paradigms supports a differentiated account of sensorimotor lateralization.
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BibTeX
@misc{chang2026regional,
title = {{Regional Heterogeneity of Sensorimotor BOLD Lateralization During Unilateral Hand Movement}},
author = {Xu Chang and Hongyu Zhou and Qingyun Wang and Zixiao Li and Yongjun Wang},
howpublished = {Research Square},
year = {2026},
month = oct,
doi = {10.21203/rs.3.rs-11254024/v1},
url = {https://doi.org/10.21203/rs.3.rs-11254024/v1},
note = {CC BY 4.0},
}
RIS
TY - UNPB
TI - Regional Heterogeneity of Sensorimotor BOLD Lateralization During Unilateral Hand Movement
AU - Xu Chang
AU - Hongyu Zhou
AU - Qingyun Wang
AU - Zixiao Li
AU - Yongjun Wang
PY - 2026
DA - 2026/10/27
PB - Research Square
DO - 10.21203/rs.3.rs-11254024/v1
UR - https://doi.org/10.21203/rs.3.rs-11254024/v1
AB - Unilateral hand movement engages contralateral sensorimotor cortex, but the balance of contralateral and ipsilateral responses can differ across regions. We quantified regional blood oxygen level-dependent lateralization in 20 CoSpine participants and compared corresponding endpoints in 100 unrelated Human Connectome Project participants. Bilateral Brainnetome parcels represented primary motor, primary somatosensory, dorsal premotor, and ventral premotor regions. Lateralization averaged the contralateral-minus-ipsilateral activation contrast across hands. CoSpine analyses used refitted activation models without physiological-recording regressors, following input qualification and correction of anatomical-mask mapping. Analyses retained five within-participant regional contrasts and a covariance-aware bootstrap sensitivity test. CoSpine composite lateralization averaged 28.059 contrast-of-parameter-estimate units (95% confidence interval 23.718–32.551). The covariance-aware analysis supported regional heterogeneity (p < 0.001). Primary motor and somatosensory regions had the largest mean lateralization, dorsal premotor cortex an intermediate mean, and ventral premotor cortex a mean near zero. Four regional contrasts survived Holm correction; the primary motor–somatosensory difference was 3.653 units (95% confidence interval − 4.559 to 13.112; adjusted p = 0.462). The independent cohort showed a similar regional pattern, with a supported primary motor–somatosensory difference and weak positive ventral premotor lateralization. These results characterize regional variation in hemispheric response balance beyond the general observation of contralateral activation. The shared atlas-level pattern across distinct motor paradigms supports a differentiated account of sensorimotor lateralization.
SN - 2693-5015
ER -