Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 20 min ago
PreprintCC BYChemRxiv

From Bench to Game Engine: An Instructor-Built Suite of 3D Laboratory Simulations Created with Generative AI

  1. 1School of Biological and Physical Sciences
  2. 2Daytona State College

Abstract

Virtual chemistry laboratories have historically required either a commercial subscription or a software development team, placing custom simulations out of reach for most instructors. I report the design and construction of a suite of browser-playable 3D laboratory simulations for a non-science-majors chemistry course that has no formal laboratory component — density of an unknown metal, pH of common solutions, double replacement reactions, separations by paper chromatography, and physical and chemical changes — that I built alone in the Unity game engine, with no prior game-development experience, using a large-language-model coding assistant connected directly to the engine. Each lab pairs a 3D fume hood, rendered by a Unity WebGL build, with an HTML worksheet that checks readings, assigns per-student unknowns, and prints a one-page report; the answer data lives in the compiled build rather than in the page, so students cannot read it from the source. The labs serve two purposes: laboratory experience for students who would otherwise have none, and continuity of instruction when hurricane closures disrupt the weekly schedule. I describe the development workflow, the division of labor between instructor and AI, the design decisions that keep the simulations chemically honest, the time and cost involved, and the limitations encountered. All builds, worksheet pages, and prelab reviews are freely available on GitHub. The approach offers a reproducible path for instructors to author their own laboratory simulations: the five described here were built in about one month.

Related

  1. Built in Minutes, Checked by Script: Instructor-Made Interactive Chemistry Study Guides with Generative AI
    John Picione
    ChemRxivPreprintLicence not statedGeneral chemistryChemRxiv
  2. Escape Rooms, Arcades, and a Grain of Salt: Five Original Games for Introductory Chemistry, Built by One Instructor with Generative AI
    John Picione
    ChemRxivPreprintLicence not statedGeneral chemistryChemRxiv
  3. Series-Parallel Testing of Laboratory Lithium-Ion Cells: Not All Coin Cells Are Created Equal
    Collin Rodmyre, Bryce Watson, Karen Ly +4
    ACS omegaPeer-reviewedCC BY-NC-NDFull textGeneral chemistryEurope PMCCrossref
  4. The Ferenczy Dataset Revisited: How HIV Protease Inhibitors Created an Illusion of Universal Size Dependence in Ligand Binding
    Xuliang Jiang
    ChemRxivPreprintCC BYFull textPhysical chemistryChemRxiv
  5. Strategy For Steganography and Information Encryption-Decryption Using Fs Laser-Created Luminescence in Organic Solids
    Ruyue Que, Olivier Plantevin, Matthieu Lancry +1
    Physical Chemistry Chemical PhysicsPeer-reviewedCC BY-NC-ND 4.0Full text1 citedMaterials & polymersTheoretical & computational chemistryHAL
BibTeX
@misc{picione2026from,
  title = {{From Bench to Game Engine: An Instructor-Built Suite of 3D Laboratory Simulations Created with Generative AI}},
  author = {John Picione},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010988/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010988/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - From Bench to Game Engine: An Instructor-Built Suite of 3D Laboratory Simulations Created with Generative AI
AU  - John Picione
PY  - 2026
DA  - 2026/10/23
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010988/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010988/v1
AB  - Virtual chemistry laboratories have historically required either a commercial subscription or a software development team, placing custom simulations out of reach for most instructors. I report the design and construction of a suite of browser-playable 3D laboratory simulations for a non-science-majors chemistry course that has no formal laboratory component — density of an unknown metal, pH of common solutions, double replacement reactions, separations by paper chromatography, and physical and chemical changes — that I built alone in the Unity game engine, with no prior game-development experience, using a large-language-model coding assistant connected directly to the engine. Each lab pairs a 3D fume hood, rendered by a Unity WebGL build, with an HTML worksheet that checks readings, assigns per-student unknowns, and prints a one-page report; the answer data lives in the compiled build rather than in the page, so students cannot read it from the source. The labs serve two purposes: laboratory experience for students who would otherwise have none, and continuity of instruction when hurricane closures disrupt the weekly schedule. I describe the development workflow, the division of labor between instructor and AI, the design decisions that keep the simulations chemically honest, the time and cost involved, and the limitations encountered. All builds, worksheet pages, and prelab reviews are freely available on GitHub. The approach offers a reproducible path for instructors to author their own laboratory simulations: the five described here were built in about one month.
ER  -