CD8+ T cell transcriptional reprogramming toward TCF7-low cytotoxicity drives immune aging in viral ARDS

The p53-p21-Cyclin D2 regulatory axis drives metabolic reprogramming and a distinct senescent macrophage senotype during aging and MASLD.
G. Torres, I. A. Salladay-Perez, C. Y. Deng +27
bioRxiv22 Sep 2026PreprintCC BY-NC-NDFull textImmunologybioRxiv
Epstein-Barr Virus in HIV-Associated Conjunctival Squamous Cell Carcinoma and Transcriptional Reprogramming of Conjunctival Epithelial Cells
H. Dochi, J. Avilala, Y. Yamada +11
bioRxiv20 Oct 2026PreprintAll rights reservedFull textMicrobiologybioRxiv
Explosive cytotoxicity of ruptoblasts bridges hormone surveillance and immune defense
Chew Chai, Eliya Sultan, Souradeep R. Sarkar +7
Cell2 Jun 2026Peer-reviewedLicence not statedFull text7 citedImmunologyOpenAlex
713 Vitamin B6-mediated lipid metabolic reprogramming as a strategy to restore antitumor T cell immunity in aging
Nicola Vannini, Helen Carrasco Hope, Claudia Cifuentes Caballero +2
Journal for ImmunoTherapy of Cancer6 Nov 2026Peer-reviewedCC BYFull textImmunologyDOAJ
Transient reprogramming limits AP-1-associated chromatin opening and transposable element activation to preserve hematopoietic stem cell function during aging and stress
A. PORQUET, M. BOHM, H. Ait-Ougouram +10
bioRxiv28 Aug 2026PreprintAll rights reservedFull textCell biologybioRxiv

Cite

BibTeX

@article{li2026cell,
  title = {{CD8+ T cell transcriptional reprogramming toward TCF7-low cytotoxicity drives immune aging in viral ARDS}},
  author = {Kuan Li and Kaibinuer Ainiwaer and Licheng Song and Jinmiao Hu and Yafan Yang and Yimeng Liu and Hongwei Li and Shiqi Xu and Youyang Wang and Juan Yin and Li Li and Xing Wang and Xiaoyang Hong and Lixin Xie and Huaiyong Chen},
  journal = {iScience},
  year = {2026},
  month = oct,
  doi = {10.1016/j.isci.2026.117774},
  url = {https://www.cell.com/iscience/fulltext/S2589-0042(26)03155-X},
  note = {CC BY 4.0},
}

RIS

TY  - JOUR
TI  - CD8+ T cell transcriptional reprogramming toward TCF7-low cytotoxicity drives immune aging in viral ARDS
AU  - Kuan Li
AU  - Kaibinuer Ainiwaer
AU  - Licheng Song
AU  - Jinmiao Hu
AU  - Yafan Yang
AU  - Yimeng Liu
AU  - Hongwei Li
AU  - Shiqi Xu
AU  - Youyang Wang
AU  - Juan Yin
AU  - Li Li
AU  - Xing Wang
AU  - Xiaoyang Hong
AU  - Lixin Xie
AU  - Huaiyong Chen
PY  - 2026
DA  - 2026/10/08
JO  - iScience
DO  - 10.1016/j.isci.2026.117774
UR  - https://www.cell.com/iscience/fulltext/S2589-0042(26)03155-X
SN  - 2589-0042
ER  -

Related

Cite