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Peer-reviewedCC BY 4.0PLOS One

Effectiveness of cold atmospheric plasma on Staphylococcus Aureus colonies on living animal tissue surface

  • Fatemeh Shakeri1
  • Hassan Mehdian2
  • Mahdiyeh Bakhtiyari-Ramezani3
  • Kamal Hajisharifi
  • Elaheh Amini
  1. 1Plasma Medicine Group, Plasma Research Institute, Kharazmi University, Tehran, Iran
  2. 2Plasma Physics and Nuclear Fusion Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
  3. 3Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
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Abstract

Staphylococcus aureus (S. aureus) is the most common pathogen associated with skin infections worldwide. Significant efforts have been made to identify and develop innovative therapeutic strategies against S. aureus as alternatives to conventional antibiotics. Physical plasma has a broad range of potential uses, with non-destructive disinfection being one of its earliest applications. Although the literature emphasizes the antibacterial properties of cold atmospheric plasma (CAP), the effect of plasma on S. aureus on damaged skin susceptible to S. aureus invasion through the itch-scratch cycle has not been studied to date. Thus, we examined the effectiveness of CAP treatment on S. aureus bacteria in atopic dermatitis lesions using floating electrode dielectric barrier discharge devices, as well as helium and argon plasma jets. Heat distribution on the skin target, ultraviolet C radiation, and ozone generation of plasma jets for the operator of plasma sources were evaluated. Microbial tests confirmed the presence of S. aureus on the lesions of the groups before treatment. The groups exposed to plasma treatment showed a notable reduction in bacterial population compared to the model group (p < 0.05). Furthermore, our investigation indicated that plasma treatment reduced pruritus behavior. The findings suggest that cold atmospheric plasma treatment may potentially target skin infections caused by S. aureus in addition to conventional therapies.

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Cite

BibTeXRIS
BibTeX
@article{shakeri2026effectiveness,
  title = {{Effectiveness of cold atmospheric plasma on Staphylococcus Aureus colonies on living animal tissue surface}},
  author = {Fatemeh Shakeri and Hassan Mehdian and Mahdiyeh Bakhtiyari-Ramezani and Kamal Hajisharifi and Elaheh Amini},
  journal = {PLOS One},
  year = {2026},
  month = sep,
  doi = {10.1371/journal.pone.0349282},
  url = {https://doi.org/10.1371/journal.pone.0349282},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Effectiveness of cold atmospheric plasma on Staphylococcus Aureus colonies on living animal tissue surface
AU  - Fatemeh Shakeri
AU  - Hassan Mehdian
AU  - Mahdiyeh Bakhtiyari-Ramezani
AU  - Kamal Hajisharifi
AU  - Elaheh Amini
PY  - 2026
DA  - 2026/09/16
JO  - PLOS One
DO  - 10.1371/journal.pone.0349282
UR  - https://doi.org/10.1371/journal.pone.0349282
AB  - Staphylococcus aureus (S. aureus) is the most common pathogen associated with skin infections worldwide. Significant efforts have been made to identify and develop innovative therapeutic strategies against S. aureus as alternatives to conventional antibiotics. Physical plasma has a broad range of potential uses, with non-destructive disinfection being one of its earliest applications. Although the literature emphasizes the antibacterial properties of cold atmospheric plasma (CAP), the effect of plasma on S. aureus on damaged skin susceptible to S. aureus invasion through the itch-scratch cycle has not been studied to date. Thus, we examined the effectiveness of CAP treatment on S. aureus bacteria in atopic dermatitis lesions using floating electrode dielectric barrier discharge devices, as well as helium and argon plasma jets. Heat distribution on the skin target, ultraviolet C radiation, and ozone generation of plasma jets for the operator of plasma sources were evaluated. Microbial tests confirmed the presence of S. aureus on the lesions of the groups before treatment. The groups exposed to plasma treatment showed a notable reduction in bacterial population compared to the model group (p < 0.05). Furthermore, our investigation indicated that plasma treatment reduced pruritus behavior. The findings suggest that cold atmospheric plasma treatment may potentially target skin infections caused by S. aureus in addition to conventional therapies.
SN  - 1932-6203
ER  -