Clinicopathologic comparison between proximal and distal colorectal cancers.
- 1Clinical Research and Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
- 2Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Abstract
Background
Different anatomical structure and physiologic function of colon and rectum guided some researchers to examine probable molecular, clinical and pathologic differences of rectal and colonic cancers. Awareness about characteristics of colorectal tumors at different anatomical sites enables better cancer control strategies.This study aimed to compare the clinicopathologic features of cecal and rectal cancers.Methods
In this cross-sectional study, Demographic, clinical and pathologic information of patients with newly diagnosed rectal and cecal cancer were statistically compared, using SPSS software.Results
98 patients with cancer of rectum and 53 patients with cancer of cecum were included, the mean age of patients with cecal cancer was significantly higher than rectal cancer (P= 0.012) and the odds of cecal cancer in patients older than 50 years old was two times more than the younger ones. The number of male patients was significantly higher than female patients in rectal cancer group comparing with cecal cancer group (P=0.016). 41.8% of patients with cecal cancer and 20.8% of patients with rectal cancer had smoking risk factor (P=0.012). Abdominal pain was more frequent in cecal cancer group (P=0.007) and the proportion of rectal bleeding was significantly higher in rectal cancer group (P=0.006). In terms of histopathologic findings, rectal tumors tend to be more differentiated than cecal cancers (P= 0.004).Conclusion
Despite the differences of proximal and distal colorectal cancers, due to the lack of enough evidence in this area, it is not possible yet to conclude whether rectal and colon cancer are distinct diseases or not.
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BibTeX
@article{shirvani2026clinicopathologic,
title = {{Clinicopathologic comparison between proximal and distal colorectal cancers.}},
author = {Javad Shokri Shirvani and Catherine Behzad and Moeen Shirchi and Mohammad Ranaee and Hemmat Gholinia},
journal = {Caspian journal of internal medicine},
year = {2026},
month = sep,
doi = {10.22088/cjim.17.3.544},
url = {https://europepmc.org/article/MED/42923657},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Clinicopathologic comparison between proximal and distal colorectal cancers.
AU - Javad Shokri Shirvani
AU - Catherine Behzad
AU - Moeen Shirchi
AU - Mohammad Ranaee
AU - Hemmat Gholinia
PY - 2026
DA - 2026/09/01
JO - Caspian journal of internal medicine
DO - 10.22088/cjim.17.3.544
UR - https://europepmc.org/article/MED/42923657
AB - Background Different anatomical structure and physiologic function of colon and rectum guided some researchers to examine probable molecular, clinical and pathologic differences of rectal and colonic cancers. Awareness about characteristics of colorectal tumors at different anatomical sites enables better cancer control strategies.This study aimed to compare the clinicopathologic features of cecal and rectal cancers.Methods In this cross-sectional study, Demographic, clinical and pathologic information of patients with newly diagnosed rectal and cecal cancer were statistically compared, using SPSS software.Results 98 patients with cancer of rectum and 53 patients with cancer of cecum were included, the mean age of patients with cecal cancer was significantly higher than rectal cancer (P= 0.012) and the odds of cecal cancer in patients older than 50 years old was two times more than the younger ones. The number of male patients was significantly higher than female patients in rectal cancer group comparing with cecal cancer group (P=0.016). 41.8% of patients with cecal cancer and 20.8% of patients with rectal cancer had smoking risk factor (P=0.012). Abdominal pain was more frequent in cecal cancer group (P=0.007) and the proportion of rectal bleeding was significantly higher in rectal cancer group (P=0.006). In terms of histopathologic findings, rectal tumors tend to be more differentiated than cecal cancers (P= 0.004).Conclusion Despite the differences of proximal and distal colorectal cancers, due to the lack of enough evidence in this area, it is not possible yet to conclude whether rectal and colon cancer are distinct diseases or not.
SN - 2008-6164
SN - 2008-6172
ER -