Characterizing Manifestations of Optical Coherence Tomography in Pulmonary Arterial Lesions

Abstract

BACKGROUND: Effective imaging is lacking for intravascular lesions in pulmonary vascular diseases. Optical coherence tomography (OCT) offers micron-level resolution, enabling improved diagnosis and treatment guidance. This study aimed to evaluate pulmonary arterial lesions using OCT. METHODS AND RESULTS: This retrospective study reviewed consecutive patients with pulmonary arterial lesions undergoing OCT at The First Affiliated Hospital of Guangzhou Medical University between August 2022 and November 2024. Patients with chronic thromboembolic pulmonary disease, Takayasu arteritis, Behçet's disease, or fibrosing mediastinitis were included in the study. Arterial lesions assessed included fresh, subacute, and chronic thrombus, vascular dissection, and other OCT findings. Seventy-two patients (median age 57.5 years [interquartile range 48.0-66.0 years]; 39 [54.17%] males) were included in the study. The OCT features were as follows: fresh thrombus showed irregular regions with marked signal attenuation; subacute thrombus appeared as intraluminal clumps surrounding the catheter; chronic thrombus presented as multichambered mesh-like structures; Takayasu arteritis and Behçet's disease exhibited bead-like eccentric intimal thickening with vacuole-like changes; fibrosing mediastinitis showed an irregular lumen with high attenuation behind the wall; and vascular dissection presented as dark areas with occasional lumen communication and a streak-like longitudinal appearance. CONCLUSIONS: OCT yields high-resolution imaging for detailed assessment of pulmonary vascular diseases and holds promise for clinical application.

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BibTeX RIS

BibTeX

@article{lin2026characterizing,
  title = {{Characterizing Manifestations of Optical Coherence Tomography in Pulmonary Arterial Lesions}},
  author = {Jielong Lin and Jiawei Long and Wenliang Guo and Xiaofeng Wu and Xinye Xia and Meiyan Chen and Dongda Zhou and Cheng Hong},
  journal = {Circulation Journal},
  year = {2026},
  month = sep,
  doi = {10.1253/circj.cj-25-0717},
  url = {https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-25-0717/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Characterizing Manifestations of Optical Coherence Tomography in Pulmonary Arterial Lesions
AU  - Jielong Lin
AU  - Jiawei Long
AU  - Wenliang Guo
AU  - Xiaofeng Wu
AU  - Xinye Xia
AU  - Meiyan Chen
AU  - Dongda Zhou
AU  - Cheng Hong
PY  - 2026
DA  - 2026/09/25
JO  - Circulation Journal
DO  - 10.1253/circj.cj-25-0717
UR  - https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-25-0717/_article
AB  - BACKGROUND: Effective imaging is lacking for intravascular lesions in pulmonary vascular diseases. Optical coherence tomography (OCT) offers micron-level resolution, enabling improved diagnosis and treatment guidance. This study aimed to evaluate pulmonary arterial lesions using OCT. METHODS AND RESULTS: This retrospective study reviewed consecutive patients with pulmonary arterial lesions undergoing OCT at The First Affiliated Hospital of Guangzhou Medical University between August 2022 and November 2024. Patients with chronic thromboembolic pulmonary disease, Takayasu arteritis, Behçet's disease, or fibrosing mediastinitis were included in the study. Arterial lesions assessed included fresh, subacute, and chronic thrombus, vascular dissection, and other OCT findings. Seventy-two patients (median age 57.5 years [interquartile range 48.0-66.0 years]; 39 [54.17%] males) were included in the study. The OCT features were as follows: fresh thrombus showed irregular regions with marked signal attenuation; subacute thrombus appeared as intraluminal clumps surrounding the catheter; chronic thrombus presented as multichambered mesh-like structures; Takayasu arteritis and Behçet's disease exhibited bead-like eccentric intimal thickening with vacuole-like changes; fibrosing mediastinitis showed an irregular lumen with high attenuation behind the wall; and vascular dissection presented as dark areas with occasional lumen communication and a streak-like longitudinal appearance. CONCLUSIONS: OCT yields high-resolution imaging for detailed assessment of pulmonary vascular diseases and holds promise for clinical application.
SN  - 1347-4820
SN  - 1346-9843
ER  -

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