Assessing a local vaccination initiative: Eight years of “Immuniser Lyon” in France
9 affiliations
- 1PHE3ID, International Center for Research in Infectiology, Inserm U1111, CNRS UMR5308, ENS de Lyon, University Lyon 1, Lyon, France
- 2Claude Bernard University, Lyon 1 University, Lyon, France
- 3Service Hygiène, Epidémiologie, Infectiovigilance et Prévention, Hospices Civils de Lyon, Lyon, France
- 4Regional health monitoring center, Auvergne-Rhône-Alpes Regional Health Agency, Lyon, France
- 5Academy of Pharmacy, Lyon, France
- 6Doctor, Former Director of Urban Ecology, Lyon, France
- 7Blossom Vaccinology, La Chapelle du Mont du Chat, France
- 8Laboratoire de Biométrie et Biologie Evolutive, CNRS UMR5558, Equipe Biostatistiques Santé, Villeurbanne, France
- 9Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, Lyon, France
Abstract
“Immuniser Lyon” (IL) is a French city-level initiative launched in 2015 to promote vaccination through coordinated, locally tailored actions. The objective of this study is to describe and compare temporal trends in vaccine coverage for HPV and influenza in the Rhône area versus the neighboring Auvergne-Rhône-Alpes (ARA) region, and to explore whether observed patterns are consistent with a potential contribution of the IL initiative. A comparative analysis of vaccine coverage was performed for HPV (2010–2022) and influenza (2016–2020) between different areas within the Auvergne-Rhône-Alpes (ARA) region versus the ARA region, using binomial log-linear models. HPV vaccine coverage in Rhône and ARA followed similar patterns, increasing from 2015 to 2022 after a nationwide decline. For influenza, vaccine coverage among adults aged ≥65 was significantly higher in Lyon in 2020 (64.5%) than in the rest of ARA (59.2%, OR=1.25, 95% CI [1.24–1.26], p < 0.001). While HPV trends reflected broader national dynamics, the observed pattern may be consistent with a potential contribution of IL to the accelerated uptake of influenza vaccines in older adults. These findings highlight the potential of sustained local action to complement national immunization strategies.
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BibTeX
@article{dessemon2026assessing,
title = {{Assessing a local vaccination initiative: Eight years of “Immuniser Lyon” in France}},
author = {Juliette Dessemon and Romain Saux and Christelle Elias and Anne-Sophie Ronnaux-Baron and Anne Sophie Malachane and Sophie Pamies-Jeantet and Benoit Soubeyrand and Pascal Roy and Philippe Vanhems},
journal = {PLOS Global Public Health},
year = {2026},
month = oct,
doi = {10.1371/journal.pgph.0007468},
url = {https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0007468},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Assessing a local vaccination initiative: Eight years of “Immuniser Lyon” in France
AU - Juliette Dessemon
AU - Romain Saux
AU - Christelle Elias
AU - Anne-Sophie Ronnaux-Baron
AU - Anne Sophie Malachane
AU - Sophie Pamies-Jeantet
AU - Benoit Soubeyrand
AU - Pascal Roy
AU - Philippe Vanhems
PY - 2026
DA - 2026/10/16
JO - PLOS Global Public Health
DO - 10.1371/journal.pgph.0007468
UR - https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0007468
AB - “Immuniser Lyon” (IL) is a French city-level initiative launched in 2015 to promote vaccination through coordinated, locally tailored actions. The objective of this study is to describe and compare temporal trends in vaccine coverage for HPV and influenza in the Rhône area versus the neighboring Auvergne-Rhône-Alpes (ARA) region, and to explore whether observed patterns are consistent with a potential contribution of the IL initiative. A comparative analysis of vaccine coverage was performed for HPV (2010–2022) and influenza (2016–2020) between different areas within the Auvergne-Rhône-Alpes (ARA) region versus the ARA region, using binomial log-linear models. HPV vaccine coverage in Rhône and ARA followed similar patterns, increasing from 2015 to 2022 after a nationwide decline. For influenza, vaccine coverage among adults aged ≥65 was significantly higher in Lyon in 2020 (64.5%) than in the rest of ARA (59.2%, OR=1.25, 95% CI [1.24–1.26], p < 0.001). While HPV trends reflected broader national dynamics, the observed pattern may be consistent with a potential contribution of IL to the accelerated uptake of influenza vaccines in older adults. These findings highlight the potential of sustained local action to complement national immunization strategies.
SN - 2767-3375
ER -