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Peer-reviewedCC BY-NC-ND 4.0BMC Infectious Diseases

Helicobacter pylori infection in French Guiana: South American or French?

  • Alolia Aboikoni1
  • Marthe Alogo1
  • Philippe Lehours2,3
  • Dominique Louvel1
  • Paul Ngock Dime1
  • Inès Fouoking1
  • Corine Fozeu1
  • Ala Ouni1
  • Larissa Tangan1
  • Mathieu Nacher4,5
  • Alexis Daude6
  • Loïc Sobanska6
2 more authors
  • Magalie Demar5,6,7
  • Vincent Sainte Rose6,7
7 affiliations
  1. 1Service d’Hépato-gastroentérologie, CHU Guyane, site de Cayenne, Cayenne, French Guiana
  2. 2Univ. Bordeaux, INSERM, BRIC U1312, Bordeaux, F-33000 France
  3. 3CHU de Bordeaux, CNR des Campylobacters et des Hélicobacters, Bordeaux, F-33000 France
  4. 4CIC INSERM 1424, CHU de Guyane, Cayenne, French Guiana
  5. 5Université de Guyane, Cayenne, Cayenne, 97300 French Guiana
  6. 6Laboratoire d’Analyses de biologie médicale, CHU de Guyane, Cayenne, French Guiana
  7. 7UMR Tropical Biome and Immunophysiopathology (TBIP)- Centre d’Infection et d’Immunité de Lille (U1019 INSERM), Université de Guyane, Cayenne, French Guiana
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Abstract

Background and aims: Helicobacter pylori (H. pylori) is a frequent infection, with a higher prevalence in developing countries. French Guiana, although French, is a region with a high level of poverty and a high incidence of gastric cancer, for which H. pylori is a known risk factor. However, epidemiological data regarding H. pylori infection in this region remain scarce. The aim of this study was to assess the prevalence of H. pylori infection and resistance to clarithromycin.

Methods: We retrospectively included all patients who underwent a gastroscopy during which gastric biopsies samples were taken for molecular biology testing, H. pylori PCR. Culture was performed if H. pylori PCR detected resistance to clarithromycin. Sex, age and place of birth were analyzed to describe the population and the factors associated with infection.

Results: A total of 443 patients were included. H. pylori PCR was positive in 174 patients (39.3%). The median age of the whole population was 56 years (42–66). There was no significant difference between the proportions of men and women infected. Infection was less common in patients aged over 50 (p = 0.013) and was more frequent in people born abroad (p = 0.001). Being born in Haiti, Brazil or Suriname-Guyana was associated with a positive H. pylori PCR test (OR = 2.47, 95% CI [1.20–5.24], p = 0.02; OR = 4.26, 95% CI [1.94–9.67], p < 0.001;OR = 4.40, 95% CI [1.70-11.76], p < 0.001 respectively), while being over 50 years of age was associated with a negative H. pylori PCR test (OR = 0.33, 95% CI [0.15–0.69], p < 0.001).Clarithromycin resistance was found in 20 (11.5%) of the infected patients. This was primary resistance in almost all cases (19/20 or 95%).

Conclusion: The prevalence of H. pylori infection on gastric biopsies is high in French Guiana, but resistance to clarithromycin is low, below the 15% threshold defined by the WHO. It is therefore important to establish a screening and treatment protocol tailored to the region.

Clinical Trial: Not applicable.

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Cite

BibTeXRIS
BibTeX
@article{aboikoni2026helicobacter,
  title = {{Helicobacter pylori infection in French Guiana: South American or French?}},
  author = {Alolia Aboikoni and Marthe Alogo and Philippe Lehours and Dominique Louvel and Paul Ngock Dime and Inès Fouoking and Corine Fozeu and Ala Ouni and Larissa Tangan and Mathieu Nacher and Alexis Daude and Loïc Sobanska and Magalie Demar and Vincent Sainte Rose},
  journal = {BMC Infectious Diseases},
  year = {2026},
  month = jul,
  doi = {10.1186/s12879-026-14109-5},
  url = {https://doi.org/10.1186/s12879-026-14109-5},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Helicobacter pylori infection in French Guiana: South American or French?
AU  - Alolia Aboikoni
AU  - Marthe Alogo
AU  - Philippe Lehours
AU  - Dominique Louvel
AU  - Paul Ngock Dime
AU  - Inès Fouoking
AU  - Corine Fozeu
AU  - Ala Ouni
AU  - Larissa Tangan
AU  - Mathieu Nacher
AU  - Alexis Daude
AU  - Loïc Sobanska
AU  - Magalie Demar
AU  - Vincent Sainte Rose
PY  - 2026
DA  - 2026/07/31
JO  - BMC Infectious Diseases
DO  - 10.1186/s12879-026-14109-5
UR  - https://doi.org/10.1186/s12879-026-14109-5
AB  - Background and aims: Helicobacter pylori (H. pylori) is a frequent infection, with a higher prevalence in developing countries. French Guiana, although French, is a region with a high level of poverty and a high incidence of gastric cancer, for which H. pylori is a known risk factor. However, epidemiological data regarding H. pylori infection in this region remain scarce. The aim of this study was to assess the prevalence of H. pylori infection and resistance to clarithromycin.  Methods: We retrospectively included all patients who underwent a gastroscopy during which gastric biopsies samples were taken for molecular biology testing, H. pylori PCR. Culture was performed if H. pylori PCR detected resistance to clarithromycin. Sex, age and place of birth were analyzed to describe the population and the factors associated with infection.  Results: A total of 443 patients were included. H. pylori PCR was positive in 174 patients (39.3%). The median age of the whole population was 56 years (42–66). There was no significant difference between the proportions of men and women infected. Infection was less common in patients aged over 50 (p = 0.013) and was more frequent in people born abroad (p = 0.001). Being born in Haiti, Brazil or Suriname-Guyana was associated with a positive H. pylori PCR test (OR = 2.47, 95% CI [1.20–5.24], p = 0.02; OR = 4.26, 95% CI [1.94–9.67], p < 0.001;OR = 4.40, 95% CI [1.70-11.76], p < 0.001 respectively), while being over 50 years of age was associated with a negative H. pylori PCR test (OR = 0.33, 95% CI [0.15–0.69], p < 0.001).Clarithromycin resistance was found in 20 (11.5%) of the infected patients. This was primary resistance in almost all cases (19/20 or 95%).  Conclusion: The prevalence of H. pylori infection on gastric biopsies is high in French Guiana, but resistance to clarithromycin is low, below the 15% threshold defined by the WHO. It is therefore important to establish a screening and treatment protocol tailored to the region.  Clinical Trial: Not applicable.
SN  - 1471-2334
ER  -