Biomarkers in Acute Mesenteric Ischemia: A Systematic Review of Diagnostic Performance and Injury-Related Signals
- 1Department of Hospital Surgery No. 2, Sechenov First Moscow State Medical University ( ), 119048 Moscow, Russia; (Z.B.); (E.K.); (D.P.); (E.T.); (A.S.); (A.K.); (A.N.); (M.I.); (S.N.); (S.M.)
- 2Cardiology Department No. 2, Yudin City Hospital of Moscow, The Patrice Lumumba (RUDN), 117198 Moscow, Russia;
Abstract
Background/Objectives: We examined nine biomarkers for acute mesenteric ischemia (AMI) detection, necrosis and postoperative prediction. Methods: PubMed/MEDLINE, the Cochrane Library and indexed citation links were searched on 10 October 2026 without a lower publication-year limit. PubMed and citation searches used an October 2026 publication cutoff. English- and Russian-language clinical reports with at least 10 participants were eligible. Narrative synthesis used QUADAS-2 and diagnostic GRADE. Results: Twenty-nine primary reports were included, with reported cohorts of 18–1479 participants. Cohort overlap and varying tested denominators precluded an unduplicated participant total. Among 28 diagnostic reports, 22 had high index-test risk and 25 had high flow/timing risk. Certainty was very low for eight markers. I-FABP, α-GST and citrulline findings depended on population, assay and timing. D-dimer, lactate, procalcitonin and ischemia-modified albumin lacked intestinal specificity. Urinary I-FABP estimates were imprecise. SM22 supplied association data without diagnostic-performance estimates. Conclusions: No evaluated marker supports reliable stand-alone exclusion of AMI or determination of bowel viability. Complementary panels require prospective validation. The injury diagrams are unvalidated research models.
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BibTeX
@article{berikkhanov2026biomarkers,
title = {{Biomarkers in Acute Mesenteric Ischemia: A Systematic Review of Diagnostic Performance and Injury-Related Signals}},
author = {Zelimkhan Berikkhanov and Zakhar Akulov and Ekaterina Klimova and David Pogosyan and Evgeniy Tarabrin and Alexey Shestakov and Aleksey Kotelnikov and Andrey Nikolaev and Vadim Razumovsky and Milena Ivanova and Mehrshad Ebrahimnezhad and Sara Nourmahal and Sergey Muraviev},
journal = {Diagnostics (Basel, Switzerland)},
year = {2026},
month = oct,
doi = {10.3390/diagnostics16203360},
url = {https://europepmc.org/article/PMC/PMC13703922},
note = {CC BY},
}
RIS
TY - JOUR
TI - Biomarkers in Acute Mesenteric Ischemia: A Systematic Review of Diagnostic Performance and Injury-Related Signals
AU - Zelimkhan Berikkhanov
AU - Zakhar Akulov
AU - Ekaterina Klimova
AU - David Pogosyan
AU - Evgeniy Tarabrin
AU - Alexey Shestakov
AU - Aleksey Kotelnikov
AU - Andrey Nikolaev
AU - Vadim Razumovsky
AU - Milena Ivanova
AU - Mehrshad Ebrahimnezhad
AU - Sara Nourmahal
AU - Sergey Muraviev
PY - 2026
DA - 2026/10/01
JO - Diagnostics (Basel, Switzerland)
DO - 10.3390/diagnostics16203360
UR - https://europepmc.org/article/PMC/PMC13703922
AB - Background/Objectives: We examined nine biomarkers for acute mesenteric ischemia (AMI) detection, necrosis and postoperative prediction. Methods: PubMed/MEDLINE, the Cochrane Library and indexed citation links were searched on 10 October 2026 without a lower publication-year limit. PubMed and citation searches used an October 2026 publication cutoff. English- and Russian-language clinical reports with at least 10 participants were eligible. Narrative synthesis used QUADAS-2 and diagnostic GRADE. Results: Twenty-nine primary reports were included, with reported cohorts of 18–1479 participants. Cohort overlap and varying tested denominators precluded an unduplicated participant total. Among 28 diagnostic reports, 22 had high index-test risk and 25 had high flow/timing risk. Certainty was very low for eight markers. I-FABP, α-GST and citrulline findings depended on population, assay and timing. D-dimer, lactate, procalcitonin and ischemia-modified albumin lacked intestinal specificity. Urinary I-FABP estimates were imprecise. SM22 supplied association data without diagnostic-performance estimates. Conclusions: No evaluated marker supports reliable stand-alone exclusion of AMI or determination of bowel viability. Complementary panels require prospective validation. The injury diagrams are unvalidated research models.
SN - 2075-4418
ER -