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Peer-reviewedCC BYBiological Psychiatry

Astrocytes Control Cocaine-Induced Synaptic Plasticity and Reward Through the Matricellular Protein Hevin

  • Raphaële Mongrédien
  • Augusto Anesio
  • Gustavo J.D. Fernandes
  • Andrew Eagle
  • Steeve Maldera
  • Cuong Pham
  • Séverine Robert
  • Fernando Bezerra
  • Adèle Vilette
  • Paula Bianchi
  • Clara Franco
  • Franck Louis
11 more authors
  • Carole Gruszczynski
  • Marie-Laure Niépon
  • Catalina Betancur
  • Amaia Erdozain
  • Alfred Robison
  • Antony Boucard
  • Fabio Cruz
  • Dongdong Li
  • Nicolas Heck
  • Sophie Gautron
  • Vincent Vialou
Open at sourcePDFDOICite

Abstract

Drug addiction involves profound modifications of neuronal plasticity in the nucleus accumbens, which may engage various cell types. Here, we report prominent effects of cocaine on calcium signals in astrocytes characterized by in vivo fiber photometry. Astrocyte calcium signals in the nucleus accumbens are sufficient and necessary for the acquisition of cocaine seeking behavior. We identify the astrocyte-secreted matricellular protein hevin as an effector of the action of cocaine and calcium signals on reward and neuronal plasticity.

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Cite

BibTeXRIS
BibTeX
@article{mongredien2026astrocytes,
  title = {{Astrocytes Control Cocaine-Induced Synaptic Plasticity and Reward Through the Matricellular Protein Hevin}},
  author = {Raphaële Mongrédien and Augusto Anesio and Gustavo J.D. Fernandes and Andrew Eagle and Steeve Maldera and Cuong Pham and Séverine Robert and Fernando Bezerra and Adèle Vilette and Paula Bianchi and Clara Franco and Franck Louis and Carole Gruszczynski and Marie-Laure Niépon and Catalina Betancur and Amaia Erdozain and Alfred Robison and Antony Boucard and Fabio Cruz and Dongdong Li and Nicolas Heck and Sophie Gautron and Vincent Vialou},
  journal = {Biological Psychiatry},
  year = {2026},
  month = oct,
  doi = {10.1016/j.biopsych.2025.02.904},
  url = {https://hal.science/hal-05780246v1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Astrocytes Control Cocaine-Induced Synaptic Plasticity and Reward Through the Matricellular Protein Hevin
AU  - Raphaële Mongrédien
AU  - Augusto Anesio
AU  - Gustavo J.D. Fernandes
AU  - Andrew Eagle
AU  - Steeve Maldera
AU  - Cuong Pham
AU  - Séverine Robert
AU  - Fernando Bezerra
AU  - Adèle Vilette
AU  - Paula Bianchi
AU  - Clara Franco
AU  - Franck Louis
AU  - Carole Gruszczynski
AU  - Marie-Laure Niépon
AU  - Catalina Betancur
AU  - Amaia Erdozain
AU  - Alfred Robison
AU  - Antony Boucard
AU  - Fabio Cruz
AU  - Dongdong Li
AU  - Nicolas Heck
AU  - Sophie Gautron
AU  - Vincent Vialou
PY  - 2026
DA  - 2026/10/06
JO  - Biological Psychiatry
DO  - 10.1016/j.biopsych.2025.02.904
UR  - https://hal.science/hal-05780246v1
AB  - Drug addiction involves profound modifications of neuronal plasticity in the nucleus accumbens, which may engage various cell types. Here, we report prominent effects of cocaine on calcium signals in astrocytes characterized by in vivo fiber photometry. Astrocyte calcium signals in the nucleus accumbens are sufficient and necessary for the acquisition of cocaine seeking behavior. We identify the astrocyte-secreted matricellular protein hevin as an effector of the action of cocaine and calcium signals on reward and neuronal plasticity.
SN  - 0006-3223
ER  -