Identifying a Shared Metabolomic Signature in Mother–Newborn Dyads With and Without Gestational Diabetes: Implications for Early Metabolic Programming
6 affiliations
- 1Pediatric Obesity Clinic and Wellness Unit, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City 06720, Mexico
- 2Division of Population Health & Biostatistics, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA
- 3Laboratorio de Genómica del Envejecimiento del INMEGEN en el Centro de Investigación sobre Envejecimiento (CIE-CINVESTAV Sede Sur), Mexico City 14330, Mexico
- 4Departamento de Ginecología y Obstetricia, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City 06720, Mexico
- 5Laboratorio de Errores Innatos del Metabolismo y Tamiz, Instituto Nacional de Pediatría, Mexico City 04530, Mexico
- 6Unidad de Genética de la Nutrición, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico
Abstract
Pregnancy is a critical window for metabolic programming, during which adverse intrauterine exposures may influence long-term health. GDM alters the intrauterine environment, but its role in early metabolic programming remains poorly understood. Thus, the objective of this study was to identify the shared metabolomic signature in mother–newborn dyads and to assess whether GDM modifies this signature. For this purpose, we conducted a cross-sectional study including mother–newborn dyads recruited at the General Hospital of Mexico. Blood samples were collected from dyads. Amino acids and acylcarnitines were quantified by tandem mass spectrometry. Sparse partial least squares (sPLS) analysis was used to identify shared metabolomic signatures within mother–newborn dyads. Linear mixed-effects models evaluated the modifying effect of GDM on shared metabolites. A total of 112 mother–newborn dyads (68 without GDM and 44 with GDM) were included. Two shared metabolomic signatures were identified. The first, characterized by arginine, methionine, acetylcarnitine, and free carnitine, showed a strong maternal–newborn correlation. Although this core signature was preserved in both groups, valine and alanine contributed exclusively to the GDM-exposed dyads. In conclusion, a shared metabolomic signature related to fetal development and energy metabolism was conserved regardless of GDM status, although GDM partially modified this signature. These findings provide insights into metabolic processes potentially involved in early metabolic programming.
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BibTeX
@article{omanaguzman2026identifying,
title = {{Identifying a Shared Metabolomic Signature in Mother–Newborn Dyads With and Without Gestational Diabetes: Implications for Early Metabolic Programming}},
author = {Isabel Omaña-Guzmán and Juan Carlos López-Alvarenga and Berenice Palacios-González and Fernanda Jaramillo-Pimentel and Luis Lanz-Pérez and Amhed Alvarado-González and Cristina Díaz-Olivares and José Alberto Carranco-Martínez and Marcela Vela-Amieva and Isabel Ibarra-González and Nayely Garibay-Nieto},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = oct,
doi = {10.3390/ijms27219786},
url = {https://www.mdpi.com/1422-0067/27/21/9786},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Identifying a Shared Metabolomic Signature in Mother–Newborn Dyads With and Without Gestational Diabetes: Implications for Early Metabolic Programming
AU - Isabel Omaña-Guzmán
AU - Juan Carlos López-Alvarenga
AU - Berenice Palacios-González
AU - Fernanda Jaramillo-Pimentel
AU - Luis Lanz-Pérez
AU - Amhed Alvarado-González
AU - Cristina Díaz-Olivares
AU - José Alberto Carranco-Martínez
AU - Marcela Vela-Amieva
AU - Isabel Ibarra-González
AU - Nayely Garibay-Nieto
PY - 2026
DA - 2026/10/31
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27219786
UR - https://www.mdpi.com/1422-0067/27/21/9786
AB - Pregnancy is a critical window for metabolic programming, during which adverse intrauterine exposures may influence long-term health. GDM alters the intrauterine environment, but its role in early metabolic programming remains poorly understood. Thus, the objective of this study was to identify the shared metabolomic signature in mother–newborn dyads and to assess whether GDM modifies this signature. For this purpose, we conducted a cross-sectional study including mother–newborn dyads recruited at the General Hospital of Mexico. Blood samples were collected from dyads. Amino acids and acylcarnitines were quantified by tandem mass spectrometry. Sparse partial least squares (sPLS) analysis was used to identify shared metabolomic signatures within mother–newborn dyads. Linear mixed-effects models evaluated the modifying effect of GDM on shared metabolites. A total of 112 mother–newborn dyads (68 without GDM and 44 with GDM) were included. Two shared metabolomic signatures were identified. The first, characterized by arginine, methionine, acetylcarnitine, and free carnitine, showed a strong maternal–newborn correlation. Although this core signature was preserved in both groups, valine and alanine contributed exclusively to the GDM-exposed dyads. In conclusion, a shared metabolomic signature related to fetal development and energy metabolism was conserved regardless of GDM status, although GDM partially modified this signature. These findings provide insights into metabolic processes potentially involved in early metabolic programming.
SN - 1422-0067
ER -