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Peer-reviewedCC BYSchizophrenia bulletin

Association between Multimorbidity and Suicidal Behaviors among People with Psychotic Disorders.

  • Alice Saito1,2
  • Florence Piché1,2
  • Katerina Kavalidou3
  • Aurelie Baillot4,5,6
  • Robert-Paul Juster2,7,8
  • Signature Consortium2
  • Ahmed J Romain1,2
8 affiliations
  1. 1School of Kinesiology and Physical Activity Sciences, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
  2. 2Centre de Recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montréal, Quebec, H1N 3V2, Canada.
  3. 3National Suicide Research Foundation, University College Cork, Cork, T12 XF62, Ireland.
  4. 4Interdisciplinary School of Health, University du Québec en Outaouais, Gatineau, Quebec, J8X 3X7, Canada.
  5. 5Institut du savoir de l'Hôpital Montfort, Ottawa, Ontario, K1K 0T2, Canada.
  6. 6Centre de recherche du Centre Intégré de Santé et Services Sociaux de l'Outaouais, Gatineau, J8V 3R2, Quebec, Canada.
  7. 7Center on Sex*Gender, Allostasis, and Resilience (CESAR), Montreal, Quebec, H1N 3V2, Canada.
  8. 8Department of Psychiatry & Addiction, University of Montreal, Montreal, Quebec, H3T 1J4, Canada.
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Abstract

Background and hypothesis

Suicide and poor health conditions are the leading causes of premature mortality in psychotic disorders. People with psychotic disorders have an increased risk of multimorbidity (≥2 chronic conditions) which could contribute to higher rates of suicidal ideation and suicide behaviors. The aim of the present study was to determine the association between multimorbidity and suicidal behaviors in people with psychotic disorders.Study design

Cross-sectional study using data from the Signature Biobank and including people with clinical diagnoses of psychotic disorders. Sociodemographic information, lifestyle habits, 22 chronic conditions, suicidal ideation (PHQ-9), and suicidal behaviors (SBQ-R) scores were gathered. Logistic regressions were performed across three models with different levels of adjustment: sociodemographics (M1), M1 adjusted for psychotic symptoms (M2), and M2 with further adjustments for lifestyle habits (M3). Sensitivity analyses were done on a subgroup of individuals with early psychosis (≤30 years old).Study results

A sample of 748 participants with diagnosis of psychotic disorder (69% male; age: 39.5 ± 14.1; 35.2% with schizophrenia was recruited. Among them, 407 participants (54%) had multimorbidity, and 44% had physical multimorbidity. After adjustment for covariates, individuals with multimorbidity were more likely to report suicidal ideations (OR 2.31, 95%CI [1.61-3.32]) and suicidal behaviors (OR 1.84, 95%CI [1.15-2.97]) than their counterparts. Similar results were found for the young psychosis subgroup (<30 years old), as for physical multimorbidity.Conclusion

Results confirmed an association between multimorbidity and higher rates of suicidal behaviors among our sample, supporting the importance of interventions to prevent the development of chronic conditions.

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Cite

BibTeXRIS
BibTeX
@article{saito2026association,
  title = {{Association between Multimorbidity and Suicidal Behaviors among People with Psychotic Disorders.}},
  author = {Alice Saito and Florence Piché and Katerina Kavalidou and Aurelie Baillot and Robert-Paul Juster and Signature Consortium and Ahmed J Romain},
  journal = {Schizophrenia bulletin},
  year = {2026},
  month = oct,
  doi = {10.1093/schbul/sbag089},
  url = {https://europepmc.org/article/MED/42960984},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Association between Multimorbidity and Suicidal Behaviors among People with Psychotic Disorders.
AU  - Alice Saito
AU  - Florence Piché
AU  - Katerina Kavalidou
AU  - Aurelie Baillot
AU  - Robert-Paul Juster
AU  - Signature Consortium
AU  - Ahmed J Romain
PY  - 2026
DA  - 2026/10/01
JO  - Schizophrenia bulletin
DO  - 10.1093/schbul/sbag089
UR  - https://europepmc.org/article/MED/42960984
AB  - Background and hypothesis  Suicide and poor health conditions are the leading causes of premature mortality in psychotic disorders. People with psychotic disorders have an increased risk of multimorbidity (≥2 chronic conditions) which could contribute to higher rates of suicidal ideation and suicide behaviors. The aim of the present study was to determine the association between multimorbidity and suicidal behaviors in people with psychotic disorders.Study design  Cross-sectional study using data from the Signature Biobank and including people with clinical diagnoses of psychotic disorders. Sociodemographic information, lifestyle habits, 22 chronic conditions, suicidal ideation (PHQ-9), and suicidal behaviors (SBQ-R) scores were gathered. Logistic regressions were performed across three models with different levels of adjustment: sociodemographics (M1), M1 adjusted for psychotic symptoms (M2), and M2 with further adjustments for lifestyle habits (M3). Sensitivity analyses were done on a subgroup of individuals with early psychosis (≤30 years old).Study results  A sample of 748 participants with diagnosis of psychotic disorder (69% male; age: 39.5 ± 14.1; 35.2% with schizophrenia was recruited. Among them, 407 participants (54%) had multimorbidity, and 44% had physical multimorbidity. After adjustment for covariates, individuals with multimorbidity were more likely to report suicidal ideations (OR 2.31, 95%CI [1.61-3.32]) and suicidal behaviors (OR 1.84, 95%CI [1.15-2.97]) than their counterparts. Similar results were found for the young psychosis subgroup (<30 years old), as for physical multimorbidity.Conclusion  Results confirmed an association between multimorbidity and higher rates of suicidal behaviors among our sample, supporting the importance of interventions to prevent the development of chronic conditions.
SN  - 1787-9965
SN  - 1745-1701
SN  - 0586-7614
ER  -