Cutaneous endothelial cells and their roles in wound healing.
- 1Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.
- 2Metro North Hospital and Health Service, Queensland Health, Brisbane, Queensland, Australia.
- 3Department of Dermatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Abstract
Endothelial cells (ECs) form the inner monolayer of blood and lymphatic vessels play an essential role in skin homeostasis and wound healing. Upon injury, ECs rapidly engage in the healing response. ECs promote wound healing by forming new blood vessels through angiogenesis to supply oxygen, nutrients, and signals needed for tissue repair. Diseases like diabetes can cause endothelial dysfunction, leading to defective neovascularization and delayed wound closure. This review focuses on the intrinsic roles of ECs in each phase of skin wound healing, extending beyond their roles in vascularization, and discusses therapeutic strategies that target those functions to improve healing outcomes. Recognizing ECs as dynamic regulators of wound repair, rather than merely structural components of blood vessels, could open new therapeutic avenues for regenerative skin therapies.
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- Poly-L-Lactic Acid Attenuates Fibrotic Remodeling During Cutaneous Wound Healing
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BibTeX
@article{li2026cutaneous,
title = {{Cutaneous endothelial cells and their roles in wound healing.}},
author = {Haiming Li and Laura Sormani Le Bourhis and Seen-Ling Sim and Abbas Shafiee and Kiarash Khosrotehrani},
journal = {JID innovations : skin science from molecules to population health},
year = {2026},
month = sep,
doi = {10.1016/j.xjidi.2026.100539},
url = {https://europepmc.org/article/MED/42909176},
note = {CC BY},
}
RIS
TY - JOUR
TI - Cutaneous endothelial cells and their roles in wound healing.
AU - Haiming Li
AU - Laura Sormani Le Bourhis
AU - Seen-Ling Sim
AU - Abbas Shafiee
AU - Kiarash Khosrotehrani
PY - 2026
DA - 2026/09/10
JO - JID innovations : skin science from molecules to population health
DO - 10.1016/j.xjidi.2026.100539
UR - https://europepmc.org/article/MED/42909176
AB - Endothelial cells (ECs) form the inner monolayer of blood and lymphatic vessels play an essential role in skin homeostasis and wound healing. Upon injury, ECs rapidly engage in the healing response. ECs promote wound healing by forming new blood vessels through angiogenesis to supply oxygen, nutrients, and signals needed for tissue repair. Diseases like diabetes can cause endothelial dysfunction, leading to defective neovascularization and delayed wound closure. This review focuses on the intrinsic roles of ECs in each phase of skin wound healing, extending beyond their roles in vascularization, and discusses therapeutic strategies that target those functions to improve healing outcomes. Recognizing ECs as dynamic regulators of wound repair, rather than merely structural components of blood vessels, could open new therapeutic avenues for regenerative skin therapies.
SN - 2667-0267
ER -