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Peer-reviewedCC BY 4.0Advanced Science

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

  • Ming Zhang1
  • Jiaxin Tian2,3
  • Xiaolong Zhu2
  • Xiao Li3
  • Xiangshu Qiu3
  • Yuanyuan Li2
  • Ben Zhong Tang4
  • Ning Shi2
4 affiliations
  1. 1State Key Laboratory Cultivation Base of Research The Affiliated Stomatological Hospital of Nanjing Medical University Prevention and Treatment for Oral Diseases Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing Medical University Nanjing China
  2. 2State Key Laboratory For Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Institute of Zoonosis and College of Veterinary Medicine Key Laboratory for Zoonosis Research of the Ministry of Education Jilin University Changchun China
  3. 3Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Changchun China
  4. 4Guangdong Basic Research Center of Excellence for Aggregate Science School of Science and Engineering The Chinese University of Hong Kong (Shenzhen) Shenzhen Guangdong China
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Abstract

The local inflammatory response and ongoing viral replication caused by monkeypox virus (MPXV) infection pose severe challenges for clinical treatment. Traditional treatment strategies are unable to achieve the dual goals of virus clearance and tissue repair simultaneously. This study innovatively adopts a hierarchical assembly strategy of “mesoporous carrier anchoring‐gel matrix embedding” to construct a functionalized hydrogel (Polymer@mPDA@Gel). Using mesoporous polydopamine (mPDA) as the exclusive anchoring site to load the polymer, forming an efficient photothermal component, and then embedding this component in a gel matrix with strong adhesion and good biocompatibility. Through hierarchical assembly, the photothermal performance, anti‐inflammatory performance, and biointerfacial properties are precisely integrated to lay the core foundation for its anti‐viral and anti‐inflammatory functions. The functionalized hydrogel constructed realizes targeted clearance of MPXV, regulation of inflammation, and integration of tissue repair, providing a new material technology path and theoretical support for the clinical treatment of MPXV infection.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026overcoming,
  title = {{Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing}},
  author = {Ming Zhang and Jiaxin Tian and Xiaolong Zhu and Xiao Li and Xiangshu Qiu and Yuanyuan Li and Ben Zhong Tang and Ning Shi},
  journal = {Advanced Science},
  year = {2026},
  month = aug,
  doi = {10.1002/advs.76926},
  url = {https://doi.org/10.1002/advs.76926},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing
AU  - Ming Zhang
AU  - Jiaxin Tian
AU  - Xiaolong Zhu
AU  - Xiao Li
AU  - Xiangshu Qiu
AU  - Yuanyuan Li
AU  - Ben Zhong Tang
AU  - Ning Shi
PY  - 2026
DA  - 2026/08/05
JO  - Advanced Science
DO  - 10.1002/advs.76926
UR  - https://doi.org/10.1002/advs.76926
AB  - The local inflammatory response and ongoing viral replication caused by monkeypox virus (MPXV) infection pose severe challenges for clinical treatment. Traditional treatment strategies are unable to achieve the dual goals of virus clearance and tissue repair simultaneously. This study innovatively adopts a hierarchical assembly strategy of “mesoporous carrier anchoring‐gel matrix embedding” to construct a functionalized hydrogel (Polymer@mPDA@Gel). Using mesoporous polydopamine (mPDA) as the exclusive anchoring site to load the polymer, forming an efficient photothermal component, and then embedding this component in a gel matrix with strong adhesion and good biocompatibility. Through hierarchical assembly, the photothermal performance, anti‐inflammatory performance, and biointerfacial properties are precisely integrated to lay the core foundation for its anti‐viral and anti‐inflammatory functions. The functionalized hydrogel constructed realizes targeted clearance of MPXV, regulation of inflammation, and integration of tissue repair, providing a new material technology path and theoretical support for the clinical treatment of MPXV infection.
SN  - 2198-3844
ER  -