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Peer-reviewedCC BY-NC-NDWorld journal of surgical oncology

Intraoperative titanium clip localization versus preoperative medical glue localization for pulmonary nodules: a prospective cohort study.

  • Jiangyu Wu1
  • Huiling Guo2
  • Wenxin Tian3
  • Hanbo Yu3
  • Donghang Li3
  • Yi Tian3
  • Peng Jiao4
4 affiliations
  1. 1Beijing Hospital, National Center for Gerontology, National Clinical Research Center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China.
  2. 2School of Mathematics and Statistics, Yunnan University, Kunming, P.R. China.
  3. 3Department of Thoracic Surgery, Beijing Hospital, National Center for Gerontology, National Clinical Research Center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No.1 Dahua Road, Dong Dan, Beijing, 100730, P.R. China.
  4. 4Department of Thoracic Surgery, Beijing Hospital, National Center for Gerontology, National Clinical Research Center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No.1 Dahua Road, Dong Dan, Beijing, 100730, P.R. China. [email protected].
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Abstract

Background

Preoperative CT-guided percutaneous localization of pulmonary nodules is widely used in clinical practice but is often associated with localization-related complications. Intraoperative titanium clip localization may provide a safer localization strategy. This study aimed to compare the effectiveness and safety of these two approaches.Methods

This single-center prospective cohort study included 189 patients who underwent pulmonary nodule resection after localization between October 2023 and November 2025. Patients were divided into an intraoperative titanium clip localization group (n = 123) and a preoperative medical glue localization group (n = 66) based on the localization method. Localization success rate, localization-related complications, and perioperative outcomes were analyzed.Results

A total of 252 pulmonary nodules were localized. The intraoperative group demonstrated a significantly higher localization success rate than the preoperative group (99.4% vs. 89.0%; OR, 18.07; 95% CI, 2.18-149.84; P = 0.007), along with a lower incidence of localization-related complications (0% vs. 30.3%; OR, 0.004). However, the duration of general anesthesia was longer in the intraoperative group (196.34 ± 54.46 vs. 162.76 ± 57.19 min; P = 0.001). There were no significant differences in postoperative drainage volume, postoperative complication rates, or length of hospital stay between the two groups.Conclusions

Intraoperative titanium clip localization demonstrated a higher localization success rate and a lower incidence of localization-related complications. It may have potential value for simultaneous localization of multiple pulmonary nodules. However, this approach was associated with a longer duration of general anesthesia.

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Cite

BibTeXRIS
BibTeX
@article{wu2026intraoperative,
  title = {{Intraoperative titanium clip localization versus preoperative medical glue localization for pulmonary nodules: a prospective cohort study.}},
  author = {Jiangyu Wu and Huiling Guo and Wenxin Tian and Hanbo Yu and Donghang Li and Yi Tian and Peng Jiao},
  journal = {World journal of surgical oncology},
  year = {2026},
  month = aug,
  doi = {10.1186/s12957-026-04484-3},
  url = {https://europepmc.org/article/MED/42958505},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Intraoperative titanium clip localization versus preoperative medical glue localization for pulmonary nodules: a prospective cohort study.
AU  - Jiangyu Wu
AU  - Huiling Guo
AU  - Wenxin Tian
AU  - Hanbo Yu
AU  - Donghang Li
AU  - Yi Tian
AU  - Peng Jiao
PY  - 2026
DA  - 2026/08/03
JO  - World journal of surgical oncology
DO  - 10.1186/s12957-026-04484-3
UR  - https://europepmc.org/article/MED/42958505
AB  - Background  Preoperative CT-guided percutaneous localization of pulmonary nodules is widely used in clinical practice but is often associated with localization-related complications. Intraoperative titanium clip localization may provide a safer localization strategy. This study aimed to compare the effectiveness and safety of these two approaches.Methods  This single-center prospective cohort study included 189 patients who underwent pulmonary nodule resection after localization between October 2023 and November 2025. Patients were divided into an intraoperative titanium clip localization group (n = 123) and a preoperative medical glue localization group (n = 66) based on the localization method. Localization success rate, localization-related complications, and perioperative outcomes were analyzed.Results  A total of 252 pulmonary nodules were localized. The intraoperative group demonstrated a significantly higher localization success rate than the preoperative group (99.4% vs. 89.0%; OR, 18.07; 95% CI, 2.18-149.84; P = 0.007), along with a lower incidence of localization-related complications (0% vs. 30.3%; OR, 0.004). However, the duration of general anesthesia was longer in the intraoperative group (196.34 ± 54.46 vs. 162.76 ± 57.19 min; P = 0.001). There were no significant differences in postoperative drainage volume, postoperative complication rates, or length of hospital stay between the two groups.Conclusions  Intraoperative titanium clip localization demonstrated a higher localization success rate and a lower incidence of localization-related complications. It may have potential value for simultaneous localization of multiple pulmonary nodules. However, this approach was associated with a longer duration of general anesthesia.
SN  - 1477-7819
ER  -