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Peer-reviewedCC BY 4.0Metabolites

Plant-Derived Anti-Virulence Metabolites Targeting Gram-Negative Phytopathogens: Recent Advances and Perspectives

  • Ying Tang1,2,3
  • Xuning Liu1,2,3
  • Cuiyang Zhang1,2,3
  • Binbin Huang1,2,3
  • Ye Li1,2,3
  • Zhaohui Guo1,2,3,4
  • Qingshu Liu1,2,3,4
  • Liyang Wu1,2,3,4
  • Jie Du1,2,3
4 affiliations
  1. 1Institute of Microbiology, Hunan Academy of Agricultural Sciences, Changsha 410125, China
  2. 2Hunan Province Engineering Research Center for Agricultural Microbiology Application, Hunan Institute of Microbiology, Changsha 410009, China
  3. 3National Collection of Plant-Associated Microbes (Hunan), Changsha 410009, China
  4. 4Changsha Technology Innovation Center for Exploration and Utilization of Agricultural Microbial Germplasm Resources, Changsha 410009, China
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Abstract

Plant specialized metabolites play important roles in plant–microbe interactions. Beyond direct antimicrobial activity, some can attenuate pathogen virulence without markedly inhibiting microbial growth. Many gram-negative phytopathogenic bacteria cause important crop diseases and possess interconnected virulence systems, providing multiple opportunities for intervention by plant-derived anti-virulence metabolites. In this review, we summarize recent advances in these metabolites against gram-negative phytopathogenic bacteria according to three functional levels: virulence signal decision-making, virulence execution, and pathogenic ecological phenotypes. Particular attention is given to the strength of mechanistic evidence, including target engagement, pathway modulation, and disease-related outcomes. We further interpret these activities in the chemical-ecology context of plant–pathogen interactions and discuss the challenges and prospects of developing plant-derived metabolites as anti-virulence agents.

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Cite

BibTeXRIS
BibTeX
@article{tang2026plantderived,
  title = {{Plant-Derived Anti-Virulence Metabolites Targeting Gram-Negative Phytopathogens: Recent Advances and Perspectives}},
  author = {Ying Tang and Xuning Liu and Cuiyang Zhang and Binbin Huang and Ye Li and Zhaohui Guo and Qingshu Liu and Liyang Wu and Jie Du},
  journal = {Metabolites},
  year = {2026},
  month = oct,
  doi = {10.3390/metabo16100768},
  url = {https://www.mdpi.com/2218-1989/16/10/768},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Plant-Derived Anti-Virulence Metabolites Targeting Gram-Negative Phytopathogens: Recent Advances and Perspectives
AU  - Ying Tang
AU  - Xuning Liu
AU  - Cuiyang Zhang
AU  - Binbin Huang
AU  - Ye Li
AU  - Zhaohui Guo
AU  - Qingshu Liu
AU  - Liyang Wu
AU  - Jie Du
PY  - 2026
DA  - 2026/10/01
JO  - Metabolites
DO  - 10.3390/metabo16100768
UR  - https://www.mdpi.com/2218-1989/16/10/768
AB  - Plant specialized metabolites play important roles in plant–microbe interactions. Beyond direct antimicrobial activity, some can attenuate pathogen virulence without markedly inhibiting microbial growth. Many gram-negative phytopathogenic bacteria cause important crop diseases and possess interconnected virulence systems, providing multiple opportunities for intervention by plant-derived anti-virulence metabolites. In this review, we summarize recent advances in these metabolites against gram-negative phytopathogenic bacteria according to three functional levels: virulence signal decision-making, virulence execution, and pathogenic ecological phenotypes. Particular attention is given to the strength of mechanistic evidence, including target engagement, pathway modulation, and disease-related outcomes. We further interpret these activities in the chemical-ecology context of plant–pathogen interactions and discuss the challenges and prospects of developing plant-derived metabolites as anti-virulence agents.
SN  - 2218-1989
ER  -