Periocular Sebaceous Carcinoma: A Rare Entity in Mexico.
- 1Dermatology, Instituto Dermatológico de Jalisco "Dr. José Barba Rubio", Zapopan, MEX.
Abstract
Sebaceous carcinoma (SC) is a malignant neoplasm arising from the sebaceous glands. Its periocular location, originating from the meibomian or Zeis glands, can clinically mimic benign lesions such as chalazion or chronic blepharitis, which may delay diagnosis. We present a case of an elderly male patient with a history of nodular basal cell carcinoma, type 2 diabetes mellitus, and systemic arterial hypertension, who presented to the dermatology clinic with an asymmetric neoformation on the right lower eyelid, reddish in color with whitish-yellow areas and ulceration with a hematic crust. Dermoscopy showed polymorphic vessels and structureless yellowish areas. Histopathological examination revealed a malignant epithelial tumor with clear-cytoplasm cells, pleomorphic nuclei, and focal necrosis, with sebaceous differentiation confirmed by immunohistochemistry positive for epithelial membrane antigen (EMA). Surgical resection with a wide safety margin and reconstruction using a Mustardé flap were performed, achieving tumor-free histological margins. Clinical and imaging follow-up showed no evidence of recurrence or metastasis. In this patient, wide local excision with complete histopathological evaluation confirmed complete removal of the lesion with clear surgical margins, with no evidence of recurrence during follow-up.
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BibTeX
@article{sol2026periocular,
title = {{Periocular Sebaceous Carcinoma: A Rare Entity in Mexico.}},
author = {Bryan Salvador Sol and Teresa Jannete Ortega Valls and Amara Hazel Solorio Rivera and Brenda Ayuzo Del Valle and Diana Maria Ibarra Tostado and Víctor Manuel Tarango-Martinez},
journal = {Cureus},
year = {2026},
month = sep,
doi = {10.7759/cureus.116780},
url = {https://europepmc.org/article/MED/42921534},
note = {CC BY},
}
RIS
TY - JOUR
TI - Periocular Sebaceous Carcinoma: A Rare Entity in Mexico.
AU - Bryan Salvador Sol
AU - Teresa Jannete Ortega Valls
AU - Amara Hazel Solorio Rivera
AU - Brenda Ayuzo Del Valle
AU - Diana Maria Ibarra Tostado
AU - Víctor Manuel Tarango-Martinez
PY - 2026
DA - 2026/09/23
JO - Cureus
DO - 10.7759/cureus.116780
UR - https://europepmc.org/article/MED/42921534
AB - Sebaceous carcinoma (SC) is a malignant neoplasm arising from the sebaceous glands. Its periocular location, originating from the meibomian or Zeis glands, can clinically mimic benign lesions such as chalazion or chronic blepharitis, which may delay diagnosis. We present a case of an elderly male patient with a history of nodular basal cell carcinoma, type 2 diabetes mellitus, and systemic arterial hypertension, who presented to the dermatology clinic with an asymmetric neoformation on the right lower eyelid, reddish in color with whitish-yellow areas and ulceration with a hematic crust. Dermoscopy showed polymorphic vessels and structureless yellowish areas. Histopathological examination revealed a malignant epithelial tumor with clear-cytoplasm cells, pleomorphic nuclei, and focal necrosis, with sebaceous differentiation confirmed by immunohistochemistry positive for epithelial membrane antigen (EMA). Surgical resection with a wide safety margin and reconstruction using a Mustardé flap were performed, achieving tumor-free histological margins. Clinical and imaging follow-up showed no evidence of recurrence or metastasis. In this patient, wide local excision with complete histopathological evaluation confirmed complete removal of the lesion with clear surgical margins, with no evidence of recurrence during follow-up.
SN - 2168-8184
ER -