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Peer-reviewedCC BYAmerican journal of physiology. Heart and circulatory physiology

Cardiac Adaptation in a Murine Iliac Arteriovenous Fistula Model and the Impact of Sex and N-Acetylcysteine Supplementation

  • Erik M. Anderson1,2
  • Victoria R. Palzkill3
  • Kyoungrae Kim3
  • Brian Fazzone1,2
  • Eric M. Kunz3
  • Qiongyao Hu1,2
  • Yong He1,2
  • Kerri A. O’Malley1,2
  • Scott A. Berceli1,2
  • Terence E. Ryan3,4
  • Salvatore T. Scali1,2
4 affiliations
  1. 1Division of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Florida, United States
  2. 2Malcom Randall Veteran Affairs Medical Center, Gainesville, Florida, United States
  3. 3Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States
  4. 4Center for Exercise Science, University of Florida, Gainesville, Florida, United States
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Abstract

This murine iliac AVF model with concurrent renal insufficiency replicates compensated cardiac hypertrophy without heart failure, matching the predominant clinical phenotype in humans unlike existing preclinical models designed to induce high-output heart failure. Cardiomyocyte mitochondrial function was studied for the first time after AVF creation. Female sex was associated with increased respiratory capacity and preserved cardiac function. NAC supplementation showed a trend toward improved mitochondrial function in females.

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Cite

BibTeXRIS
BibTeX
@article{anderson2026cardiac,
  title = {{Cardiac Adaptation in a Murine Iliac Arteriovenous Fistula Model and the Impact of Sex and N-Acetylcysteine Supplementation}},
  author = {Erik M. Anderson and Victoria R. Palzkill and Kyoungrae Kim and Brian Fazzone and Eric M. Kunz and Qiongyao Hu and Yong He and Kerri A. O’Malley and Scott A. Berceli and Terence E. Ryan and Salvatore T. Scali},
  journal = {American journal of physiology. Heart and circulatory physiology},
  year = {2026},
  month = oct,
  doi = {10.1152/ajpheart.90253.2026},
  url = {https://doi.org/10.1152/ajpheart.90253.2026},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Cardiac Adaptation in a Murine Iliac Arteriovenous Fistula Model and the Impact of Sex and N-Acetylcysteine Supplementation
AU  - Erik M. Anderson
AU  - Victoria R. Palzkill
AU  - Kyoungrae Kim
AU  - Brian Fazzone
AU  - Eric M. Kunz
AU  - Qiongyao Hu
AU  - Yong He
AU  - Kerri A. O’Malley
AU  - Scott A. Berceli
AU  - Terence E. Ryan
AU  - Salvatore T. Scali
PY  - 2026
DA  - 2026/10/05
JO  - American journal of physiology. Heart and circulatory physiology
DO  - 10.1152/ajpheart.90253.2026
UR  - https://doi.org/10.1152/ajpheart.90253.2026
AB  - This murine iliac AVF model with concurrent renal insufficiency replicates compensated cardiac hypertrophy without heart failure, matching the predominant clinical phenotype in humans unlike existing preclinical models designed to induce high-output heart failure. Cardiomyocyte mitochondrial function was studied for the first time after AVF creation. Female sex was associated with increased respiratory capacity and preserved cardiac function. NAC supplementation showed a trend toward improved mitochondrial function in females.
SN  - 0363-6135
SN  - 1522-1539
ER  -