Peer-reviewedCC BY-NC-ND 4.0Bioconjugate Chemistry
Lipid and Carbohydrate Modifications Enhance Potency of Antisense Oligonucleotides Targeting Oncogenic KRAS
Abstract
One prominent open question in the field of antisense oligonucleotide remains the intracellular delivery of active sequences. While different strategies have been developed for addressing this issue, including formulation and/or conjugation approaches, multiconjugations with both sugars and nucleolipids have not been investigated so far. In this contribution, we are interested in a new hypothesis that focuses on the double conjugation of oligonucleotides with both glucose-thymine and nucleolipid moieties. The lipid carbohydrate modified antisense oligonucleotides were the most efficient in down regulating the expression of KRAS in pancreatic cancer cells.
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BibTeX
@article{kivunga2026lipid,
title = {{Lipid and Carbohydrate Modifications Enhance Potency of Antisense Oligonucleotides Targeting Oncogenic KRAS}},
author = {Faith Kivunga and Julien Verget and Helene Pereira and Brune Vialet and Patricia Korczak and Virginie Baylot and Jean Dessolin and Philippe Barthélémy},
journal = {Bioconjugate Chemistry},
year = {2026},
month = nov,
doi = {10.1021/acs.bioconjchem.5c00627},
url = {https://hal.science/hal-05732826v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Lipid and Carbohydrate Modifications Enhance Potency of Antisense Oligonucleotides Targeting Oncogenic KRAS
AU - Faith Kivunga
AU - Julien Verget
AU - Helene Pereira
AU - Brune Vialet
AU - Patricia Korczak
AU - Virginie Baylot
AU - Jean Dessolin
AU - Philippe Barthélémy
PY - 2026
DA - 2026/11/04
JO - Bioconjugate Chemistry
DO - 10.1021/acs.bioconjchem.5c00627
UR - https://hal.science/hal-05732826v1
AB - One prominent open question in the field of antisense oligonucleotide remains the intracellular delivery of active sequences. While different strategies have been developed for addressing this issue, including formulation and/or conjugation approaches, multiconjugations with both sugars and nucleolipids have not been investigated so far. In this contribution, we are interested in a new hypothesis that focuses on the double conjugation of oligonucleotides with both glucose-thymine and nucleolipid moieties. The lipid carbohydrate modified antisense oligonucleotides were the most efficient in down regulating the expression of KRAS in pancreatic cancer cells.
SN - 1043-1802
SN - 1520-4812
ER -