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Peer-reviewedCC BY-NC-NDJournal of nanobiotechnology

Synergistic promotion of white-to-beige adipocyte transition by manganese-nucleic acid framework and allicin for alleviating obesity.

  • Teng Wang1
  • Bingxin Huangfu1
  • Shurong He1
  • Fengyi Han1
  • Jiayi Gao1
  • Jinru Chen1
  • Wentao Xu1,2
  • Kunlun Huang1,2
  • Xiaoyun He3,4
4 affiliations
  1. 1Key Laboratory of Precision Nutrition and Food Quality, Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
  2. 2Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), The Ministry of Agriculture and Rural Affairs of the P.R. China, Beijing, 100083, China.
  3. 3Key Laboratory of Precision Nutrition and Food Quality, Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China. [email protected].
  4. 4Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), The Ministry of Agriculture and Rural Affairs of the P.R. China, Beijing, 100083, China. [email protected].
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Abstract

Long-term obesity treatment remains challenging due to high costs, adverse drug effects, and invasive surgical procedures. Here, we develop an adipocyte-targeted manganese-nucleic acid framework (MNF) with superoxide dismutase (SOD)-like activity. The MNF and allicin are co-encapsulated into a silk fibroin-sulfobutylether-β-cyclodextrin (SFSC) microneedle patch, enabling minimally invasive transdermal delivery specifically to subcutaneous adipose tissue. The combination of MNF and allicin exhibits synergistic effects in alleviating oxidative stress, reducing lipid accumulation, and suppressing M1 macrophage polarization and inflammation. Notably, treatment with MNF was observed to increase intracellular NAD⁺ levels, while allicin upregulates the SIRT1 signaling pathway. This cooperative action appears to engage the NAD⁺-SIRT1 axis, promoting a phenotypic shift of white adipocytes towards beige adipocytes. Collectively, this microneedle-based delivery system, which promotes a beige-like adipocyte phenotype through dual modulation, presents a promising strategy for long-term obesity management.

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Cite

BibTeXRIS
BibTeX
@article{wang2026synergistic,
  title = {{Synergistic promotion of white-to-beige adipocyte transition by manganese-nucleic acid framework and allicin for alleviating obesity.}},
  author = {Teng Wang and Bingxin Huangfu and Shurong He and Fengyi Han and Jiayi Gao and Jinru Chen and Wentao Xu and Kunlun Huang and Xiaoyun He},
  journal = {Journal of nanobiotechnology},
  year = {2026},
  month = aug,
  doi = {10.1186/s12951-026-04857-6},
  url = {https://europepmc.org/article/MED/42958258},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Synergistic promotion of white-to-beige adipocyte transition by manganese-nucleic acid framework and allicin for alleviating obesity.
AU  - Teng Wang
AU  - Bingxin Huangfu
AU  - Shurong He
AU  - Fengyi Han
AU  - Jiayi Gao
AU  - Jinru Chen
AU  - Wentao Xu
AU  - Kunlun Huang
AU  - Xiaoyun He
PY  - 2026
DA  - 2026/08/01
JO  - Journal of nanobiotechnology
DO  - 10.1186/s12951-026-04857-6
UR  - https://europepmc.org/article/MED/42958258
AB  - Long-term obesity treatment remains challenging due to high costs, adverse drug effects, and invasive surgical procedures. Here, we develop an adipocyte-targeted manganese-nucleic acid framework (MNF) with superoxide dismutase (SOD)-like activity. The MNF and allicin are co-encapsulated into a silk fibroin-sulfobutylether-β-cyclodextrin (SFSC) microneedle patch, enabling minimally invasive transdermal delivery specifically to subcutaneous adipose tissue. The combination of MNF and allicin exhibits synergistic effects in alleviating oxidative stress, reducing lipid accumulation, and suppressing M1 macrophage polarization and inflammation. Notably, treatment with MNF was observed to increase intracellular NAD⁺ levels, while allicin upregulates the SIRT1 signaling pathway. This cooperative action appears to engage the NAD⁺-SIRT1 axis, promoting a phenotypic shift of white adipocytes towards beige adipocytes. Collectively, this microneedle-based delivery system, which promotes a beige-like adipocyte phenotype through dual modulation, presents a promising strategy for long-term obesity management.
SN  - 1477-3155
ER  -