The Impact of Nicotine Usage Across Body Contouring Surgery Outcomes and Opioid Usage
- 1Division of Plastic and Reconstructive Surgery, Indiana University School of Medicine, 545 Barnhill Drive, Emerson Hall 232, Indianapolis, IN 46202 USA
- 2Penn State College of Medicine, Hershey, PA USA
Abstract
Background:: Nicotine use is a well-established risk factor for surgical wound complications and overall postoperative morbidity;however, its impact on elective aesthetic procedures such as body contouring surgery remains poorly characterized.
Methods:: Using a large de-identifi ed electronic health record database (TriNetX), adult patients who underwent bodycontouring procedures between 2005 and 2025 were identifi ed and propensity score matched based on history ofnicotine dependence. Postoperative outcomes at 90-days were compared between patients with and withoutnicotine dependence, including wound complications, complications requiring operative intervention, seroma,venous thromboembolism, and opioid prescriptions.
Results:: A total of 110,287 patients were identifi ed. After matching, each cohort had 17,065 patients. At 90-dayspostoperatively, patients with nicotine dependence demonstrated signifi cantly higher odds of wound complications,wound complications requiring operative intervention, seroma formation, and opioid prescriptions compared to non-nicotine users. No signifi cant diff erences were observed in venous thromboembolism rates between groups.
Conclusion:: These fi ndings suggest that nicotine dependence is associated with increased postoperative morbidity followingbody contouring procedures, particularly with respect to wound-related complications and opioid utilization. Routinepreoperative nicotine screening, patient education, and cessation interventions may play an important role inmitigating postoperative complications and improving outcomes in patients undergoing elective aesthetic bodycontouring surgery
Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00266-026-06033-5.
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BibTeX
@article{sidhu2026impact,
title = {{The Impact of Nicotine Usage Across Body Contouring Surgery Outcomes and Opioid Usage}},
author = {Angad S. Sidhu and Avani A. Chopra and Daniel J. Konig and George S. Corpuz and Cynthia Sung and Aanya Chopra and Cristiane M. Ueno and Mary E. Lester and Ivan Hadad},
journal = {Aesthetic Plastic Surgery},
year = {2026},
month = jul,
doi = {10.1007/s00266-026-06033-5},
url = {https://doi.org/10.1007/s00266-026-06033-5},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - The Impact of Nicotine Usage Across Body Contouring Surgery Outcomes and Opioid Usage
AU - Angad S. Sidhu
AU - Avani A. Chopra
AU - Daniel J. Konig
AU - George S. Corpuz
AU - Cynthia Sung
AU - Aanya Chopra
AU - Cristiane M. Ueno
AU - Mary E. Lester
AU - Ivan Hadad
PY - 2026
DA - 2026/07/29
JO - Aesthetic Plastic Surgery
DO - 10.1007/s00266-026-06033-5
UR - https://doi.org/10.1007/s00266-026-06033-5
AB - Background:: Nicotine use is a well-established risk factor for surgical wound complications and overall postoperative morbidity;however, its impact on elective aesthetic procedures such as body contouring surgery remains poorly characterized. Methods:: Using a large de-identifi ed electronic health record database (TriNetX), adult patients who underwent bodycontouring procedures between 2005 and 2025 were identifi ed and propensity score matched based on history ofnicotine dependence. Postoperative outcomes at 90-days were compared between patients with and withoutnicotine dependence, including wound complications, complications requiring operative intervention, seroma,venous thromboembolism, and opioid prescriptions. Results:: A total of 110,287 patients were identifi ed. After matching, each cohort had 17,065 patients. At 90-dayspostoperatively, patients with nicotine dependence demonstrated signifi cantly higher odds of wound complications,wound complications requiring operative intervention, seroma formation, and opioid prescriptions compared to non-nicotine users. No signifi cant diff erences were observed in venous thromboembolism rates between groups. Conclusion:: These fi ndings suggest that nicotine dependence is associated with increased postoperative morbidity followingbody contouring procedures, particularly with respect to wound-related complications and opioid utilization. Routinepreoperative nicotine screening, patient education, and cessation interventions may play an important role inmitigating postoperative complications and improving outcomes in patients undergoing elective aesthetic bodycontouring surgery Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00266-026-06033-5.
SN - 0364-216X
SN - 1432-5241
ER -