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Peer-reviewedCC BYHuman Genome Variation

Varporter: a software platform for comprehensive genomic profiling (CGP) in cancer

  • Masashi Idogawa1
  • Kohichi Takada2
  • Tasuku Mariya3
  • Aki Ishikawa3
  • Satoshi Iyama4
  • Tsuyoshi Saito5
  • Hiroshi Nakase6
  • Masayoshi Kobune4
  • Akihiro Sakurai3
6 affiliations
  1. 1Division of Medical Genome Sciences, Department of Genomic and Preventive Medicine, Sapporo Medical University School of Medicine
  2. 2Division of Medical Oncology, Department of Internal Medicine, Sapporo Medical University School of Medicine
  3. 3Division of Clinical Genomics, Department of Genomic and Preventive Medicine, Sapporo Medical University School of Medicine
  4. 4Division of Hematology, Department of Internal Medicine, Sapporo Medical University School of Medicine
  5. 5Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine
  6. 6Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sapporo Medical University School of Medicine
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Abstract

The use of comprehensive genomic profiling (CGP) in cancer, also known as cancer gene panel tests, continues to expand; however, the interpretation of the results of these tests requires a tremendous amount of manual work. To improve the efficiency of this evaluation process, we developed the CGP support software named Varporter. This software automatically imports multiple data files and can display various information contained within the CGP results. In tumor-only tests, TP53 variants often require pathogenicity evaluation as presumed germline pathogenic variants. Varporter enables the automated determination of several criteria in the Variant Interpretation Guidelines established by the ClinGen TP53 Variant Curation Expert Panel. Direct links to the websites on therapeutic evidence are also automatically generated from each variant, and multiple test reports can be summarized onto a single sheet, thus making it easy to review newly added variants to clinical trials. Varporter has made it possible to automate and streamline complicated manual tasks related to CGP evaluation and to redirect human resources to more essential tasks. Varporter is designed for use with two CGP tests covered by Japanese national health insurance, FoundationOne CDx and Guardant360 CDx.

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Cite

BibTeXRIS
BibTeX
@article{idogawa2026varporter,
  title = {{Varporter: a software platform for comprehensive genomic profiling (CGP) in cancer}},
  author = {Masashi Idogawa and Kohichi Takada and Tasuku Mariya and Aki Ishikawa and Satoshi Iyama and Tsuyoshi Saito and Hiroshi Nakase and Masayoshi Kobune and Akihiro Sakurai},
  journal = {Human Genome Variation},
  year = {2026},
  month = jul,
  doi = {10.1038/s41439-026-00357-z},
  url = {https://doi.org/10.1038/s41439-026-00357-z},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Varporter: a software platform for comprehensive genomic profiling (CGP) in cancer
AU  - Masashi Idogawa
AU  - Kohichi Takada
AU  - Tasuku Mariya
AU  - Aki Ishikawa
AU  - Satoshi Iyama
AU  - Tsuyoshi Saito
AU  - Hiroshi Nakase
AU  - Masayoshi Kobune
AU  - Akihiro Sakurai
PY  - 2026
DA  - 2026/07/01
JO  - Human Genome Variation
DO  - 10.1038/s41439-026-00357-z
UR  - https://doi.org/10.1038/s41439-026-00357-z
AB  - The use of comprehensive genomic profiling (CGP) in cancer, also known as cancer gene panel tests, continues to expand; however, the interpretation of the results of these tests requires a tremendous amount of manual work. To improve the efficiency of this evaluation process, we developed the CGP support software named Varporter. This software automatically imports multiple data files and can display various information contained within the CGP results. In tumor-only tests, TP53 variants often require pathogenicity evaluation as presumed germline pathogenic variants. Varporter enables the automated determination of several criteria in the Variant Interpretation Guidelines established by the ClinGen TP53 Variant Curation Expert Panel. Direct links to the websites on therapeutic evidence are also automatically generated from each variant, and multiple test reports can be summarized onto a single sheet, thus making it easy to review newly added variants to clinical trials. Varporter has made it possible to automate and streamline complicated manual tasks related to CGP evaluation and to redirect human resources to more essential tasks. Varporter is designed for use with two CGP tests covered by Japanese national health insurance, FoundationOne CDx and Guardant360 CDx.
SN  - 2054-345X
ER  -