Epidemiological model selection unravels the molecular processes of antiviral resistance from experimental phytoplankton-virus dynamics
Abstract
Phytoplankton-virus interactions are pivotal in understanding the intertwined dynamics of these key players of the global carbon cycle. Although antiviral resistance is the main hypothesis to solve the apparent paradox of their coexistence, identifying its molecular determinisms and mechanisms, as well as their dynamical consequences, remains challenging. By combining hypotheses about such determinisms and mechanisms, we designed 36 dynamical models and fitted them to experimental infection kinetics in a pioneering selection model approach. Through such a multiple hypotheses testing, we identified that resistance in the model species Ostreococcus tauri is most likely to be predominantly intracellular, to control lysis through budding, and to be acquired by phenotypic plasticity. We further showed that viral kinetics are strongly impacted by both the antiviral resistance’s molecular determinants and virions’ inactivation through attachment to lysis detritus, as the latter generates a key negative feedback loop during the ‘bust’ stage of the interaction dynamics.
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BibTeX
@misc{rousseau2026epidemiological,
title = {{Epidemiological model selection unravels the molecular processes of antiviral resistance from experimental phytoplankton-virus dynamics}},
author = {Raphaël Rousseau and Claire Bugnot and Amandin James and Sheree Yau and Gwenaël Piganeau and Sébastien Gourbière},
howpublished = {HAL},
year = {2026},
month = oct,
doi = {10.64898/2026.10.06.757099},
url = {https://hal.science/hal-05785032v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - UNPB
TI - Epidemiological model selection unravels the molecular processes of antiviral resistance from experimental phytoplankton-virus dynamics
AU - Raphaël Rousseau
AU - Claire Bugnot
AU - Amandin James
AU - Sheree Yau
AU - Gwenaël Piganeau
AU - Sébastien Gourbière
PY - 2026
DA - 2026/10/06
PB - HAL
DO - 10.64898/2026.10.06.757099
UR - https://hal.science/hal-05785032v1
AB - Phytoplankton-virus interactions are pivotal in understanding the intertwined dynamics of these key players of the global carbon cycle. Although antiviral resistance is the main hypothesis to solve the apparent paradox of their coexistence, identifying its molecular determinisms and mechanisms, as well as their dynamical consequences, remains challenging. By combining hypotheses about such determinisms and mechanisms, we designed 36 dynamical models and fitted them to experimental infection kinetics in a pioneering selection model approach. Through such a multiple hypotheses testing, we identified that resistance in the model species Ostreococcus tauri is most likely to be predominantly intracellular, to control lysis through budding, and to be acquired by phenotypic plasticity. We further showed that viral kinetics are strongly impacted by both the antiviral resistance’s molecular determinants and virions’ inactivation through attachment to lysis detritus, as the latter generates a key negative feedback loop during the ‘bust’ stage of the interaction dynamics.
ER -