Improving the detection, assessment, management and prevention of delirium in palliative care units (the DAMPen-Delirium II study): protocol for an implementation-to-target Type III hybrid effectiveness-implementation cluster randomised-controlled trial, economic evaluation and process evaluation of the Creating Learning Environments for Compassionate Care-Palliative (CLECC-Pal) implementation strategy.
11 affiliations
- 1Wolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, UK.
- 2Hull Health Trials Unit, University of Hull, Hull, UK.
- 3Institute of Clinical & Applied Health Research, Hull York Medical School, University of Hull, Hull, UK.
- 4Public Co-investigator and Chair of Public Advisory Group, Manchester, UK.
- 5City Health Care Partnership CIC, Hull, UK.
- 6School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
- 7Cicely Saunders Institute of Palliative Care, Policy & Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, Kings College London, London, UK.
- 8School of Medicine, Trinity College Dublin, Dublin, Ireland.
- 9The University of Notre Dame, Darlinghurst, Sydney, Australia.
- 10University of Technology Sydney, Sydney, Australia.
- 11Wolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, UK. [email protected].
Abstract
Background
Delirium affects up to two-thirds of palliative care unit (PCU) inpatients, causing distress for patients, families, and staff, and contributing to complex care needs and increased healthcare resource use. Although evidence-based guidelines exist, their consistent implementation in PCUs is limited, and implementation strategies to support guideline-adherent care have not been rigorously evaluated in this setting. Creating Learning Environments for Compassionate Care-Palliative Delirium (CLECC-Pal Delirium) is a co-designed multi-component implementation strategy to help embed guideline-adherent delirium care within routine PCU practice. This cluster randomised controlled trial (cRCT) evaluates the effectiveness and cost-effectiveness of the implementation strategy using an implementation-to-target design, with embedded economic and process evaluations.Methods
Adaptive implementation-to-target, Type III hybrid effectiveness-implementation parallel group cRCT across 20 PCUs (10 per arm, ~ 50 patient records per cluster at each timepoint) in the UK, randomised 1:1 to CLECC-Pal Delirium or usual care. Randomisation is stratified by unit size, education provision, and provider type (NHS/Charity). Sites will receive tailored support to achieve predefined implementation-readiness criteria prior to data collection. The primary outcome is the proportion of each admission's inpatient days affected by delirium (delirium days), measured retrospectively using a validated chart-based method adapted for palliative care. Secondary outcomes include adherence to delirium care guidelines, patient symptom burden, functional status, and incremental cost-effectiveness. The sample size (1200 admission episodes with delirium) provides 92.3% power to detect a 12% absolute reduction in delirium days, based on an assumed intracluster correlation coefficient (ICC) of 0.03 (α = 0.05). Mixed-effects regression models, with clustering at the PCU level, will be employed to analyse the primary outcome, adjusting for stratification factors and other prespecified covariates, and conducted on an intention-to-treat basis. Blinded statisticians and health economists will conduct analyses. The process evaluation, guided by Normalisation Process Theory, will examine implementation fidelity and how, why, and in what contexts the strategy is integrated into practice.Discussion
This trial will provide evidence on the clinical- and cost-effectiveness of an implementation strategy to improve delirium care in PCUs, strengthening the implementation evidence base in a setting where implementation research is limited.Trial registration
ISRCTN23678136; registered 14th April 2025.
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BibTeX
@article{jackson2026improving,
title = {{Improving the detection, assessment, management and prevention of delirium in palliative care units (the DAMPen-Delirium II study): protocol for an implementation-to-target Type III hybrid effectiveness-implementation cluster randomised-controlled trial, economic evaluation and process evaluation of the Creating Learning Environments for Compassionate Care-Palliative (CLECC-Pal) implementation strategy.}},
author = {Gillian Jackson and Grant Constable and Bronwen Williams and Judith Cohen and Chao Huang and Julie Halliwell and Helen Roberts and Daniel Harman and Paul Taylor and Peter May and Alicia O'Cathain and Annmarie Hosie and Meera Agar and Miriam Johnson and Fliss E M Murtagh and Mark Pearson},
journal = {Implementation science : IS},
year = {2026},
month = jul,
doi = {10.1186/s13012-026-01522-2},
url = {https://europepmc.org/article/MED/42919390},
note = {CC BY},
}
RIS
TY - JOUR
TI - Improving the detection, assessment, management and prevention of delirium in palliative care units (the DAMPen-Delirium II study): protocol for an implementation-to-target Type III hybrid effectiveness-implementation cluster randomised-controlled trial, economic evaluation and process evaluation of the Creating Learning Environments for Compassionate Care-Palliative (CLECC-Pal) implementation strategy.
AU - Gillian Jackson
AU - Grant Constable
AU - Bronwen Williams
AU - Judith Cohen
AU - Chao Huang
AU - Julie Halliwell
AU - Helen Roberts
AU - Daniel Harman
AU - Paul Taylor
AU - Peter May
AU - Alicia O'Cathain
AU - Annmarie Hosie
AU - Meera Agar
AU - Miriam Johnson
AU - Fliss E M Murtagh
AU - Mark Pearson
PY - 2026
DA - 2026/07/01
JO - Implementation science : IS
DO - 10.1186/s13012-026-01522-2
UR - https://europepmc.org/article/MED/42919390
AB - Background Delirium affects up to two-thirds of palliative care unit (PCU) inpatients, causing distress for patients, families, and staff, and contributing to complex care needs and increased healthcare resource use. Although evidence-based guidelines exist, their consistent implementation in PCUs is limited, and implementation strategies to support guideline-adherent care have not been rigorously evaluated in this setting. Creating Learning Environments for Compassionate Care-Palliative Delirium (CLECC-Pal Delirium) is a co-designed multi-component implementation strategy to help embed guideline-adherent delirium care within routine PCU practice. This cluster randomised controlled trial (cRCT) evaluates the effectiveness and cost-effectiveness of the implementation strategy using an implementation-to-target design, with embedded economic and process evaluations.Methods Adaptive implementation-to-target, Type III hybrid effectiveness-implementation parallel group cRCT across 20 PCUs (10 per arm, ~ 50 patient records per cluster at each timepoint) in the UK, randomised 1:1 to CLECC-Pal Delirium or usual care. Randomisation is stratified by unit size, education provision, and provider type (NHS/Charity). Sites will receive tailored support to achieve predefined implementation-readiness criteria prior to data collection. The primary outcome is the proportion of each admission's inpatient days affected by delirium (delirium days), measured retrospectively using a validated chart-based method adapted for palliative care. Secondary outcomes include adherence to delirium care guidelines, patient symptom burden, functional status, and incremental cost-effectiveness. The sample size (1200 admission episodes with delirium) provides 92.3% power to detect a 12% absolute reduction in delirium days, based on an assumed intracluster correlation coefficient (ICC) of 0.03 (α = 0.05). Mixed-effects regression models, with clustering at the PCU level, will be employed to analyse the primary outcome, adjusting for stratification factors and other prespecified covariates, and conducted on an intention-to-treat basis. Blinded statisticians and health economists will conduct analyses. The process evaluation, guided by Normalisation Process Theory, will examine implementation fidelity and how, why, and in what contexts the strategy is integrated into practice.Discussion This trial will provide evidence on the clinical- and cost-effectiveness of an implementation strategy to improve delirium care in PCUs, strengthening the implementation evidence base in a setting where implementation research is limited.Trial registration ISRCTN23678136; registered 14th April 2025.
SN - 1748-5908
ER -