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Peer-reviewedCC BY-NCAnnals of dermatology

Clinic-Based Proportion of Psoriatic Arthritis and HLA-B27 Distribution in Korean Psoriasis Patients: A Retrospective Study.

  • Yeon Woo Jung1
  • Shinwon Hwang2
  • Tae-Gyun Kim3
  1. 1Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
  2. 2Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea. [email protected].
  3. 3Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea. [email protected].
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Abstract

Background

Psoriatic arthritis (PsA) develops in up to one-third of patients with psoriasis over the disease course, and the genetic factors are thought to modulate susceptibility. Although HLA-B27 has long been implicated in PsA, its clinical utility for identifying PsA in East Asian populations remains uncertain.Objective

We aimed to estimate the clinic-based prevalence of PsA among Korean psoriatic patients, and to evaluate the diagnostic value of HLA-B27, along with other clinical markers, for PsA.Methods

We conducted a retrospective, cross-sectional study of 209 patients with psoriasis who presented for their initial dermatology clinic visit at a tertiary referral center.Results

The clinic-based prevalence of PsA was 13.9%. HLA-B27 positivity did not show significant difference between patients with PsA and psoriasis not fulfilling Classification Criteria for Psoriatic Arthritis criteria (13.8% vs. 7.8%) and was not associated with PsA or cutaneous disease severity in multivariable analyses. In contrast, nail dystrophy and elevated C-reactive protein (CRP) levels were independently associated with PsA. In this cohort, HLA-B27 demonstrated limited predictive value, whereas nail involvement and elevated CRP levels emerged as more reliable indicators of joint involvement.Conclusion

In this dermatology-based cohort of unselected Korean patients with psoriasis at the initial clinic visit, routine HLA-B27 testing showed limited utility as a screening tool for PsA, whereas nail involvement and elevated CRP levels served as more practical clinical cues for closer joint involvement.

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Cite

BibTeXRIS
BibTeX
@article{jung2026clinicbased,
  title = {{Clinic-Based Proportion of Psoriatic Arthritis and HLA-B27 Distribution in Korean Psoriasis Patients: A Retrospective Study.}},
  author = {Yeon Woo Jung and Shinwon Hwang and Tae-Gyun Kim},
  journal = {Annals of dermatology},
  year = {2026},
  month = oct,
  doi = {10.5021/ad.26.027},
  url = {https://europepmc.org/article/MED/42845206},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Clinic-Based Proportion of Psoriatic Arthritis and HLA-B27 Distribution in Korean Psoriasis Patients: A Retrospective Study.
AU  - Yeon Woo Jung
AU  - Shinwon Hwang
AU  - Tae-Gyun Kim
PY  - 2026
DA  - 2026/10/01
JO  - Annals of dermatology
DO  - 10.5021/ad.26.027
UR  - https://europepmc.org/article/MED/42845206
AB  - Background  Psoriatic arthritis (PsA) develops in up to one-third of patients with psoriasis over the disease course, and the genetic factors are thought to modulate susceptibility. Although HLA-B27 has long been implicated in PsA, its clinical utility for identifying PsA in East Asian populations remains uncertain.Objective  We aimed to estimate the clinic-based prevalence of PsA among Korean psoriatic patients, and to evaluate the diagnostic value of HLA-B27, along with other clinical markers, for PsA.Methods  We conducted a retrospective, cross-sectional study of 209 patients with psoriasis who presented for their initial dermatology clinic visit at a tertiary referral center.Results  The clinic-based prevalence of PsA was 13.9%. HLA-B27 positivity did not show significant difference between patients with PsA and psoriasis not fulfilling Classification Criteria for Psoriatic Arthritis criteria (13.8% vs. 7.8%) and was not associated with PsA or cutaneous disease severity in multivariable analyses. In contrast, nail dystrophy and elevated C-reactive protein (CRP) levels were independently associated with PsA. In this cohort, HLA-B27 demonstrated limited predictive value, whereas nail involvement and elevated CRP levels emerged as more reliable indicators of joint involvement.Conclusion  In this dermatology-based cohort of unselected Korean patients with psoriasis at the initial clinic visit, routine HLA-B27 testing showed limited utility as a screening tool for PsA, whereas nail involvement and elevated CRP levels served as more practical clinical cues for closer joint involvement.
SN  - 1013-9087
SN  - 2005-3894
ER  -