Skip to content
DraconiticResearch
Search Sources API
201,683 studies31 sourcesUpdated 14 min ago
Peer-reviewedCC BY-NC 3.0RSC Advances

Cytotoxic metabolites from the endophytic fungus Penicillium sp. ArD1 derived from Corchorus olitorius seeds

  • Arwa Mortada Ahmed1
  • Islam M. Abdel-Rahman2
  • Jiabao Zhang3
  • Jianye Zhang3
  • Jun Wu4
  • Usama Ramadan Abdelmohsen1,5
  • Mostafa A. Fouad5,6
  • Basma Khalaf Mahmoud5,6
6 affiliations
  1. 1Department of Pharmacognosy, Faculty of Pharmacy, Deraya University 61111 New-Minia City Egypt
  2. 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University 61111 New-Minia Egypt
  3. 3Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University Guangzhou 511436 China
  4. 4Guangdong Key Laboratory for Research and Development of Natural Drugs, College of Pharmacy, Guangdong Medical University Dongguan 523808 China
  5. 5Department of Pharmacognosy, Faculty of Pharmacy, Minia University Minia 61519 Egypt
  6. 6Department of Pharmacognosy, Faculty of Pharmacy, Minia National University (MNU) New-Minia Egypt
Read full textPDFDOICite

Abstract

Corchorus olitorius L. seeds are a rich source of endophytic fungi, which afford many cytotoxic secondary metabolites. The fungus was taxonomically identified via sequencing as Penicillium sp. ArD1 (GenBank accession OQ520320; 99.82% similarity to P. oxalicum strain MK371716.1). The fungal extract was subjected to chromatographic separation, leading to the isolation and structural elucidation of four compounds: two naphtho-pyrones ((1) and (2)), the cyclic pentapeptide malformin A1 (3), and the fatty acid Tridecanoic acid (4). Structures were confirmed using extensive 1D and 2D NMR as well as mass spectrometry. The isolated metabolites were evaluated for cytotoxicity against human lung carcinoma cell lines A549 and H1299. Among the isolated metabolites, malformin A1 (3) exhibited the most pronounced cytotoxic activity against the tested non-small-cell lung cancer cell lines, A549 and H1299. Molecular docking analysis further suggested a possible interaction of malformin A1 with MMP-9. These findings highlight the biological activity of malformin A1 and support further investigation of its cytotoxic effects and possible molecular mechanisms.

Related

  1. Integrative BSA-seq and time-course RNA-seq prioritize candidate loci and genes associated with whole-plant cadmium (Cd) accumulation and tolerance in dark jute (Corchorus olitorius L.).
    Xu Jian-Tang, Zhu Shixin, Victoria Oluwapelumi Akintayo +8
    BMC plant biologyPeer-reviewedCC BY-NC-NDFull textGenetics & genomicsEurope PMCDOAJ
  2. Molecular-networking-based characterization of cytotoxic metabolites produced by the cyanobacterium Nostoc edaphicum CCNP1411
    Robert Konkel, Marta Cegłowska, Łukasz Grabowski +5
    Molecular DiversityPeer-reviewedCC BY-NC-ND 4.0Full textMicrobiologyPMC
  3. Inhibitory effects of propyl paraben, citral, and gallic acid on the growth, patulin biosynthesis, and patulin biosynthetic gene expression of Penicillium paneum OM1
    Ji-Yeon Koo, Sung-Yong Hong, Ae-Son Om
    Frontiers in microbiologyPeer-reviewedCC BYFull textMicrobiologyEurope PMC
  4. Efficacy and mechanistic insights of Kluyveromyces marxianus cell wall in enhancing pear fruit resistance against Penicillium expansum
    Yalan Wu, Xin-ai Chen, Ting Yu +1
    Food Innovation and AdvancesPeer-reviewedCC BYFull textPlant biologyDOAJ
  5. Cheese adaptation beyond Penicillium: contrasting genomic trajectories in the distantly related Nectriaceae molds
    L. D. Peck, J.-L. Jany, M. Coton +6
    bioRxivPreprintCC BYFull textEvolutionary biologybioRxiv

Cite

BibTeXRIS
BibTeX
@article{ahmed2026cytotoxic,
  title = {{Cytotoxic metabolites from the endophytic fungus Penicillium sp. ArD1 derived from Corchorus olitorius seeds}},
  author = {Arwa Mortada Ahmed and Islam M. Abdel-Rahman and Jiabao Zhang and Jianye Zhang and Jun Wu and Usama Ramadan Abdelmohsen and Mostafa A. Fouad and Basma Khalaf Mahmoud},
  journal = {RSC Advances},
  year = {2026},
  month = nov,
  doi = {10.1039/d6ra04888a},
  url = {https://doi.org/10.1039/d6ra04888a},
  note = {CC BY-NC 3.0},
}
RIS
TY  - JOUR
TI  - Cytotoxic metabolites from the endophytic fungus Penicillium sp. ArD1 derived from Corchorus olitorius seeds
AU  - Arwa Mortada Ahmed
AU  - Islam M. Abdel-Rahman
AU  - Jiabao Zhang
AU  - Jianye Zhang
AU  - Jun Wu
AU  - Usama Ramadan Abdelmohsen
AU  - Mostafa A. Fouad
AU  - Basma Khalaf Mahmoud
PY  - 2026
DA  - 2026/11/05
JO  - RSC Advances
DO  - 10.1039/d6ra04888a
UR  - https://doi.org/10.1039/d6ra04888a
AB  - Corchorus olitorius L. seeds are a rich source of endophytic fungi, which afford many cytotoxic secondary metabolites. The fungus was taxonomically identified via sequencing as Penicillium sp. ArD1 (GenBank accession OQ520320; 99.82% similarity to P. oxalicum strain MK371716.1). The fungal extract was subjected to chromatographic separation, leading to the isolation and structural elucidation of four compounds: two naphtho-pyrones ((1) and (2)), the cyclic pentapeptide malformin A1 (3), and the fatty acid Tridecanoic acid (4). Structures were confirmed using extensive 1D and 2D NMR as well as mass spectrometry. The isolated metabolites were evaluated for cytotoxicity against human lung carcinoma cell lines A549 and H1299. Among the isolated metabolites, malformin A1 (3) exhibited the most pronounced cytotoxic activity against the tested non-small-cell lung cancer cell lines, A549 and H1299. Molecular docking analysis further suggested a possible interaction of malformin A1 with MMP-9. These findings highlight the biological activity of malformin A1 and support further investigation of its cytotoxic effects and possible molecular mechanisms.
SN  - 2046-2069
ER  -