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Peer-reviewedCC BYJournal of clinical medicine

Chronic Rhinosinusitis Is Associated with Lower Airway Mucus Plugging

  • Akane Masuda1
  • Yuta Kono1
  • Ryo Maruyama2
  • Haruka Motohashi1
  • Naoya Aoshiba1
  • Mariko Kogami1
  • Mayuko Ishiwari1
  • Ryota Kikuchi1
  • Kenichi Kobayashi1
  • Kiyoaki Tsukahara2
  • Shinji Abe1
  1. 1Department of Respiratory Medicine, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
  2. 2Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
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Abstract

Background: Chronic rhinosinusitis (CRS) is associated with lower airway diseases, but its relationship with mucus plugging remains unclear. We investigated the association between CRS and lower airway mucus plugging. Methods: This single-center retrospective observational study included patients who underwent paranasal sinus computed tomography and chest high-resolution computed tomography. Associations between CRS and mucus plugging were evaluated, including phenotype-stratified analyses according to eosinophilic CRS (ECRS) status. Results: Among 97 patients, 51 had CRS and 46 did not. Mucus plugging was more frequent in patients with CRS than in those without CRS (41.2% vs. 10.9%, p = 0.001), and mucus plug scores were higher in the CRS group (p = 0.002). CRS remained independently associated with mucus plugging after adjustment for asthma and bronchiectasis (adjusted odds ratio, 4.06; 95% confidence interval, 1.30–12.7; p = 0.016). Mucus plugging was more prevalent in both the non-ECRS and ECRS groups than in the non-CRS group, with no significant difference between the two CRS phenotypes. Conclusions: CRS remained associated with mucus plugging after adjustment for asthma and bronchiectasis. Mucus plugging may represent an underrecognized radiological feature of the lower airways in CRS.

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Cite

BibTeXRIS
BibTeX
@article{masuda2026chronic,
  title = {{Chronic Rhinosinusitis Is Associated with Lower Airway Mucus Plugging}},
  author = {Akane Masuda and Yuta Kono and Ryo Maruyama and Haruka Motohashi and Naoya Aoshiba and Mariko Kogami and Mayuko Ishiwari and Ryota Kikuchi and Kenichi Kobayashi and Kiyoaki Tsukahara and Shinji Abe},
  journal = {Journal of clinical medicine},
  year = {2026},
  month = sep,
  doi = {10.3390/jcm15197609},
  url = {https://europepmc.org/article/PMC/PMC13665754},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Chronic Rhinosinusitis Is Associated with Lower Airway Mucus Plugging
AU  - Akane Masuda
AU  - Yuta Kono
AU  - Ryo Maruyama
AU  - Haruka Motohashi
AU  - Naoya Aoshiba
AU  - Mariko Kogami
AU  - Mayuko Ishiwari
AU  - Ryota Kikuchi
AU  - Kenichi Kobayashi
AU  - Kiyoaki Tsukahara
AU  - Shinji Abe
PY  - 2026
DA  - 2026/09/30
JO  - Journal of clinical medicine
DO  - 10.3390/jcm15197609
UR  - https://europepmc.org/article/PMC/PMC13665754
AB  - Background: Chronic rhinosinusitis (CRS) is associated with lower airway diseases, but its relationship with mucus plugging remains unclear. We investigated the association between CRS and lower airway mucus plugging. Methods: This single-center retrospective observational study included patients who underwent paranasal sinus computed tomography and chest high-resolution computed tomography. Associations between CRS and mucus plugging were evaluated, including phenotype-stratified analyses according to eosinophilic CRS (ECRS) status. Results: Among 97 patients, 51 had CRS and 46 did not. Mucus plugging was more frequent in patients with CRS than in those without CRS (41.2% vs. 10.9%, p = 0.001), and mucus plug scores were higher in the CRS group (p = 0.002). CRS remained independently associated with mucus plugging after adjustment for asthma and bronchiectasis (adjusted odds ratio, 4.06; 95% confidence interval, 1.30–12.7; p = 0.016). Mucus plugging was more prevalent in both the non-ECRS and ECRS groups than in the non-CRS group, with no significant difference between the two CRS phenotypes. Conclusions: CRS remained associated with mucus plugging after adjustment for asthma and bronchiectasis. Mucus plugging may represent an underrecognized radiological feature of the lower airways in CRS.
SN  - 2077-0383
ER  -