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Peer-reviewedCC BYFrontiers in medicine

Simultaneous presentation of vulvar aggressive angiomyxoma and ipsilateral subcutaneous lipoma: a case report.

  • Eiman Shalabna1,2
  • Mariana Ordonez1,2
  • Erika Gandelsman1,2
  • Ariel Polonsky1,2
  • Ilan Bruchim1,2
  • Benjamin Feiner1,2
  1. 1Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
  2. 2Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera, Israel.
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Abstract

Aggressive angiomyxoma (AAM) is a rare, locally infiltrative mesenchymal neoplasm of the pelviperineal region that is frequently misdiagnosed owing to its slow growth and nonspecific presentation. Synchronous presentation with a second, unrelated large soft-tissue tumor has not previously been described. We report a 53-year-old woman presenting with two sizeable, ipsilateral, left-sided masses: a pedunculated 13-cm vulvar lesion and a 30-cm multilobulated thigh mass. Ultrasound depicted the vulvar lesion as cystic; MRI favored AAM in the vulvar region and raised concern for liposarcoma in the thigh; initial biopsies were inconclusive. A multidisciplinary tumor board directed staged surgical excision. Histopathology confirmed vulvar AAM with estrogen receptor, progesterone receptor, and CD34 positivity and desmin and smooth muscle actin negativity, and a benign subcutaneous lipoma in the thigh, with no MDM2 amplification on fluorescence in situ hybridization. The postoperative course was uncomplicated. This unusual concurrent presentation illustrates the diagnostic challenges posed by AAM and underscores the value of advanced imaging, definitive histopathological confirmation, and coordinated multidisciplinary planning. Given the high risk of local recurrence, long-term surveillance remains essential.

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Cite

BibTeXRIS
BibTeX
@article{shalabna2026simultaneous,
  title = {{Simultaneous presentation of vulvar aggressive angiomyxoma and ipsilateral subcutaneous lipoma: a case report.}},
  author = {Eiman Shalabna and Mariana Ordonez and Erika Gandelsman and Ariel Polonsky and Ilan Bruchim and Benjamin Feiner},
  journal = {Frontiers in medicine},
  year = {2026},
  month = oct,
  doi = {10.3389/fmed.2026.1967076},
  url = {https://europepmc.org/article/MED/42953018},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Simultaneous presentation of vulvar aggressive angiomyxoma and ipsilateral subcutaneous lipoma: a case report.
AU  - Eiman Shalabna
AU  - Mariana Ordonez
AU  - Erika Gandelsman
AU  - Ariel Polonsky
AU  - Ilan Bruchim
AU  - Benjamin Feiner
PY  - 2026
DA  - 2026/10/14
JO  - Frontiers in medicine
DO  - 10.3389/fmed.2026.1967076
UR  - https://europepmc.org/article/MED/42953018
AB  - Aggressive angiomyxoma (AAM) is a rare, locally infiltrative mesenchymal neoplasm of the pelviperineal region that is frequently misdiagnosed owing to its slow growth and nonspecific presentation. Synchronous presentation with a second, unrelated large soft-tissue tumor has not previously been described. We report a 53-year-old woman presenting with two sizeable, ipsilateral, left-sided masses: a pedunculated 13-cm vulvar lesion and a 30-cm multilobulated thigh mass. Ultrasound depicted the vulvar lesion as cystic; MRI favored AAM in the vulvar region and raised concern for liposarcoma in the thigh; initial biopsies were inconclusive. A multidisciplinary tumor board directed staged surgical excision. Histopathology confirmed vulvar AAM with estrogen receptor, progesterone receptor, and CD34 positivity and desmin and smooth muscle actin negativity, and a benign subcutaneous lipoma in the thigh, with no MDM2 amplification on fluorescence in situ hybridization. The postoperative course was uncomplicated. This unusual concurrent presentation illustrates the diagnostic challenges posed by AAM and underscores the value of advanced imaging, definitive histopathological confirmation, and coordinated multidisciplinary planning. Given the high risk of local recurrence, long-term surveillance remains essential.
SN  - 2296-858X
ER  -