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Peer-reviewedLicence not statedCancer discovery

CDK8 inhibition induces Mediator trapping and impairment of the EWSR1::FLI1 transcriptional program in Ewing sarcoma

  • James H. McGinnis1,2
  • Shuai Wang1
  • Ryan A. O’Hara3
  • Xin Zhao3
  • Purbita Saha3
  • Xin Bai1
  • Danielle Sherry1,2
  • Jiwoong Kim4,5
  • Alberto Bremauntz Enriquez1,2
  • Jacinth Naidoo2
  • Florentina Vandiver1
  • Hanspeter Niederstrasser2
13 more authors
  • Shuguang Wei2
  • Prema L. Mallipeddi2
  • Yang Xie4,5
  • Lianbo Li2,6
  • Cynthia J. Meyer2,6
  • Jessica A. Kilgore2
  • Altair L. Dube3
  • Kenneth D. Westover2,6
  • Bruce A. Posner2
  • Noelle S. Williams2
  • Joseph M. Ready2
  • Laura A Banaszynski3,6
  • David G. McFadden1,2,6,7
7 affiliations
  1. 1Department of Internal Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
  2. 2Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
  3. 3Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, 75390
  4. 4Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  5. 5Department of Health Data Science and Biostatistics, O’Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
  6. 6Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
  7. 7Section of Molecular Medicine, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
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Cite

BibTeXRIS
BibTeX
@article{mcginnis2026cdk8,
  title = {{CDK8 inhibition induces Mediator trapping and impairment of the EWSR1::FLI1 transcriptional program in Ewing sarcoma}},
  author = {James H. McGinnis and Shuai Wang and Ryan A. O’Hara and Xin Zhao and Purbita Saha and Xin Bai and Danielle Sherry and Jiwoong Kim and Alberto Bremauntz Enriquez and Jacinth Naidoo and Florentina Vandiver and Hanspeter Niederstrasser and Shuguang Wei and Prema L. Mallipeddi and Yang Xie and Lianbo Li and Cynthia J. Meyer and Jessica A. Kilgore and Altair L. Dube and Kenneth D. Westover and Bruce A. Posner and Noelle S. Williams and Joseph M. Ready and Laura A Banaszynski and David G. McFadden},
  journal = {Cancer discovery},
  year = {2026},
  month = nov,
  doi = {10.1158/2159-8290.cd-25-1336},
  url = {https://doi.org/10.1158/2159-8290.cd-25-1336},
}
RIS
TY  - JOUR
TI  - CDK8 inhibition induces Mediator trapping and impairment of the EWSR1::FLI1 transcriptional program in Ewing sarcoma
AU  - James H. McGinnis
AU  - Shuai Wang
AU  - Ryan A. O’Hara
AU  - Xin Zhao
AU  - Purbita Saha
AU  - Xin Bai
AU  - Danielle Sherry
AU  - Jiwoong Kim
AU  - Alberto Bremauntz Enriquez
AU  - Jacinth Naidoo
AU  - Florentina Vandiver
AU  - Hanspeter Niederstrasser
AU  - Shuguang Wei
AU  - Prema L. Mallipeddi
AU  - Yang Xie
AU  - Lianbo Li
AU  - Cynthia J. Meyer
AU  - Jessica A. Kilgore
AU  - Altair L. Dube
AU  - Kenneth D. Westover
AU  - Bruce A. Posner
AU  - Noelle S. Williams
AU  - Joseph M. Ready
AU  - Laura A Banaszynski
AU  - David G. McFadden
PY  - 2026
DA  - 2026/11/02
JO  - Cancer discovery
DO  - 10.1158/2159-8290.cd-25-1336
UR  - https://doi.org/10.1158/2159-8290.cd-25-1336
SN  - 2159-8274
SN  - 2159-8290
ER  -