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Peer-reviewedCC BY-NC-NDJournal of dental sciences

Heat shock factor 1 promotes cell migration and predicts poor prognosis in oral squamous cell carcinoma.

  • Fang-Yu Wu1,2
  • Hui-Hsin Ko1,3,4,5
  • Wen-Ren Lin6
  • Shih-Jung Cheng1,3,4,7
7 affiliations
  1. 1Department of Dentistry, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan.
  2. 2Department of Dentistry, National Taiwan University Hospital, Jinshan Branch, New Taipei, Taiwan.
  3. 3Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
  4. 4School of Dentistry, National Taiwan University, Taipei, Taiwan.
  5. 5National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
  6. 6Private Clinic, Charm Dental Clinic, New Taipei City, Taiwan.
  7. 7Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
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Abstract

Background/purpose

Heat shock factor 1 (HSF1) regulates heat shock proteins and stress-responsive genes and has been implicated in tumor progression and poor prognosis in several malignancies. However, the clinicopathological significance and biological role of HSF1 in oral squamous cell carcinoma (OSCC) remain unclear. This study investigated HSF1 expression in OSCC tissues, its association with clinicopathological parameters and survival, and its functional role in OSCC cell migration.Materials and methods

HSF1 expression was evaluated by immunohistochemical staining in 80 OSCC specimens and 20 normal oral mucosa samples. HSF1 immunoreactivity was quantified using the labeling index (LI). Associations between HSF1 LI and clinicopathological parameters were analyzed. Kaplan-Meier survival analysis and Cox proportional hazards regression were performed. The effect of HSF1 downregulation on OSCC cell migration was examined in vitro.Results

HSF1 expression was significantly increased in OSCC tissues compared with normal oral mucosa. Higher HSF1 LI was significantly associated with advanced T classification, nodal metastasis, and advanced clinical stage. Multivariate Cox regression analysis identified advanced T classification, positive nodal status, and high HSF1 LI as independent prognostic factors for overall survival. Patients with HSF1 LI > 53% showed increased mortality risk. In vitro experiments demonstrated that HSF1 downregulation reduced OSCC cell migration.Conclusion

HSF1 is overexpressed in OSCC and is associated with tumor progression, advanced stage, and poor prognosis. HSF1 may also contribute to OSCC cell migration, suggesting its potential as a prognostic biomarker and therapeutic target in OSCC.

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Cite

BibTeXRIS
BibTeX
@article{wu2026heat,
  title = {{Heat shock factor 1 promotes cell migration and predicts poor prognosis in oral squamous cell carcinoma.}},
  author = {Fang-Yu Wu and Hui-Hsin Ko and Wen-Ren Lin and Shih-Jung Cheng},
  journal = {Journal of dental sciences},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jds.2025.07.3513},
  url = {https://europepmc.org/article/MED/42924143},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Heat shock factor 1 promotes cell migration and predicts poor prognosis in oral squamous cell carcinoma.
AU  - Fang-Yu Wu
AU  - Hui-Hsin Ko
AU  - Wen-Ren Lin
AU  - Shih-Jung Cheng
PY  - 2026
DA  - 2026/10/01
JO  - Journal of dental sciences
DO  - 10.1016/j.jds.2025.07.3513
UR  - https://europepmc.org/article/MED/42924143
AB  - Background/purpose  Heat shock factor 1 (HSF1) regulates heat shock proteins and stress-responsive genes and has been implicated in tumor progression and poor prognosis in several malignancies. However, the clinicopathological significance and biological role of HSF1 in oral squamous cell carcinoma (OSCC) remain unclear. This study investigated HSF1 expression in OSCC tissues, its association with clinicopathological parameters and survival, and its functional role in OSCC cell migration.Materials and methods  HSF1 expression was evaluated by immunohistochemical staining in 80 OSCC specimens and 20 normal oral mucosa samples. HSF1 immunoreactivity was quantified using the labeling index (LI). Associations between HSF1 LI and clinicopathological parameters were analyzed. Kaplan-Meier survival analysis and Cox proportional hazards regression were performed. The effect of HSF1 downregulation on OSCC cell migration was examined in vitro.Results  HSF1 expression was significantly increased in OSCC tissues compared with normal oral mucosa. Higher HSF1 LI was significantly associated with advanced T classification, nodal metastasis, and advanced clinical stage. Multivariate Cox regression analysis identified advanced T classification, positive nodal status, and high HSF1 LI as independent prognostic factors for overall survival. Patients with HSF1 LI > 53% showed increased mortality risk. In vitro experiments demonstrated that HSF1 downregulation reduced OSCC cell migration.Conclusion  HSF1 is overexpressed in OSCC and is associated with tumor progression, advanced stage, and poor prognosis. HSF1 may also contribute to OSCC cell migration, suggesting its potential as a prognostic biomarker and therapeutic target in OSCC.
SN  - 1991-7902
SN  - 2213-8862
ER  -