“Pseudolymphomatous” angiosarcoma mimicking rhinophyma — case report and focused review of the literature
Abstract
BackgroundRhinophyma is usually considered a benign late-stage manifestation of rosacea and is often treated for functional or aesthetic reasons. However, malignant tumors may clinically resemble or arise within rhinophymatous tissue. Cutaneous angiosarcoma is an aggressive vascular malignancy that predominantly affects elderly patients and may present with deceptively nonspecific inflammatory or rosacea-like changes.MethodsCase report and focused PubMed/MEDLINE literature review was performed for angiosarcoma mimicking rhinophyma or rosacea-like disease and for malignancies detected in rhinophyma.ResultsA rare case of angiosarcoma mimicking recurrent rhinophyma is presented. The literature overview includes nine previously reported cases directly associated with rhinophyma and rosacea-like presentations. Other malignancies e.g. basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) are more frequent with occurrence rates of about 1-10%.ConclusionAggressive malignancies may be concealed within recurrent rhinophyma, even in the absence of clinically suspicious features. Routine histopathological examination of all surgically removed rhinophyma tissue is therefore mandatory.
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BibTeX
@article{thimsen2026pseudolymphomatous,
title = {{“Pseudolymphomatous” angiosarcoma mimicking rhinophyma — case report and focused review of the literature}},
author = {Vivian Thimsen and Matti Sievert and Mika Gehrking and Abbas Agaimy and Sarina Müller},
journal = {Frontiers in Oncology},
year = {2026},
month = nov,
doi = {10.3389/fonc.2026.1964013},
url = {https://www.frontiersin.org/articles/10.3389/fonc.2026.1964013},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - “Pseudolymphomatous” angiosarcoma mimicking rhinophyma — case report and focused review of the literature
AU - Vivian Thimsen
AU - Matti Sievert
AU - Mika Gehrking
AU - Abbas Agaimy
AU - Sarina Müller
PY - 2026
DA - 2026/11/03
JO - Frontiers in Oncology
DO - 10.3389/fonc.2026.1964013
UR - https://www.frontiersin.org/articles/10.3389/fonc.2026.1964013
AB - BackgroundRhinophyma is usually considered a benign late-stage manifestation of rosacea and is often treated for functional or aesthetic reasons. However, malignant tumors may clinically resemble or arise within rhinophymatous tissue. Cutaneous angiosarcoma is an aggressive vascular malignancy that predominantly affects elderly patients and may present with deceptively nonspecific inflammatory or rosacea-like changes.MethodsCase report and focused PubMed/MEDLINE literature review was performed for angiosarcoma mimicking rhinophyma or rosacea-like disease and for malignancies detected in rhinophyma.ResultsA rare case of angiosarcoma mimicking recurrent rhinophyma is presented. The literature overview includes nine previously reported cases directly associated with rhinophyma and rosacea-like presentations. Other malignancies e.g. basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) are more frequent with occurrence rates of about 1-10%.ConclusionAggressive malignancies may be concealed within recurrent rhinophyma, even in the absence of clinically suspicious features. Routine histopathological examination of all surgically removed rhinophyma tissue is therefore mandatory.
SN - 2234-943X
ER -