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Peer-reviewedCC BYResponsive materials

Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application

  • Li Li1
  • Xue Wu1
  • Zekun Yan1
  • Jianmin Wu1
  • Caishi Huang2
  • Songnan Qu1,3,4
4 affiliations
  1. 1Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials Engineering University of Macau Taipa Macau SAR China
  2. 2Faculty of Health Science University of Macau Taipa Macau SAR China
  3. 3MOE Frontier Science Centre for Precision Oncology University of Macau Taipa Macao SAR China
  4. 4Zhuhai UM Science & Technology Research Institute Zhuhai China
Open at sourceDOICite

Abstract

Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in the field of cancer immunotherapy in recent years. The generation of reactive oxygen species (ROS) via photo‐responsive carbon dots (CDs) represents a novel strategy to induce pyroptosis, offering potential for clinical translation due to its biosafety and non‐invasive property. This review first introduces the mechanisms and relevant pathways of pyroptosis, followed by the summary of the main design strategies for high‐performance photo‐responsive CDs. Most importantly, we highlight the reported CDs that induce pyroptosis through photo‐triggered ROS generation and summarize the key factors governing this process. Collectively, this review may provide new insights and guidance for researchers in designing optimized photo‐responsive CDs for tumor cell pyroptosis.

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Cite

BibTeXRIS
BibTeX
@article{li2026photoresponsive,
  title = {{Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application}},
  author = {Li Li and Xue Wu and Zekun Yan and Jianmin Wu and Caishi Huang and Songnan Qu},
  journal = {Responsive materials},
  year = {2026},
  month = jun,
  doi = {10.1002/rpm2.70067},
  url = {https://doi.org/10.1002/rpm2.70067},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application
AU  - Li Li
AU  - Xue Wu
AU  - Zekun Yan
AU  - Jianmin Wu
AU  - Caishi Huang
AU  - Songnan Qu
PY  - 2026
DA  - 2026/06/28
JO  - Responsive materials
DO  - 10.1002/rpm2.70067
UR  - https://doi.org/10.1002/rpm2.70067
AB  - Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in the field of cancer immunotherapy in recent years. The generation of reactive oxygen species (ROS) via photo‐responsive carbon dots (CDs) represents a novel strategy to induce pyroptosis, offering potential for clinical translation due to its biosafety and non‐invasive property. This review first introduces the mechanisms and relevant pathways of pyroptosis, followed by the summary of the main design strategies for high‐performance photo‐responsive CDs. Most importantly, we highlight the reported CDs that induce pyroptosis through photo‐triggered ROS generation and summarize the key factors governing this process. Collectively, this review may provide new insights and guidance for researchers in designing optimized photo‐responsive CDs for tumor cell pyroptosis.
SN  - 2834-894X
SN  - 2834-8966
ER  -