Prognostic Role of TP53 and ARID1A Mutations in Alcohol-Consuming Patients With Uterine Endometrioid Carcinoma
- 1Centre for Public Health, Queen’s University Belfast, School of Medicine, Dentistry and Biomedical Sciences, Belfast, United Kingdom
- 2Department of Epidemiology, Centre for Public Health, Pamukkale University Faculty of Medicine, Denizli, Türkiye
Abstract
Uterine endometrioid carcinoma (UEC) is the most common subtype of endometrial cancer. This study aimed to investigate the prognostic relevance of TP53 and ARID1A mutations in alcohol-consuming UEC patients using publicly available TCGA data. A total of 207 UEC patients were identified from the TCGA CPTAC-3 project. Alcohol consumption status was extracted from self-reported clinical data. Patients were grouped into alcohol consumers and nonconsumers. Kaplan-Meier survival estimates and multivariable Cox proportional hazards models were used to evaluate the association between gene mutation status and overall survival, adjusted for age, stage, and grade. Sensitivity analyses excluded deaths within the first year. Out of 207 patients, 47 (22.7%) reported alcohol consumption. TP53 mutations were more prevalent in alcohol consumers compared with nonconsumers (36.2% vs. 21.3%, P=0.037). In the alcohol-consuming subgroup, patients with wild-type TP53 had significantly worse survival than those with TP53 mutations in sensitivity analysis (HR=2.85; 95% CI: 1.01-8.05; P=0.047). ARID1A wild-type status was associated with increased mortality risk compared with mutated ARID1A in adjusted models (HR=4.00; 95% CI: 1.45-11.01; P=0.007). No statistically significant survival differences were found for PTEN, PIK3CA, or KRAS mutations. TP53 and ARID1A mutation status may have prognostic relevance among alcohol-consuming patients with UEC. These findings suggest a possible gene-environment interaction in endometrial cancer and support the need for further validation through prospective studies.
Related
- The prognostic value of KRAS, NRAS, and BRAF genes mutations in patients with newly diagnosed multiple myeloma.
- Association of VCP/p97 Expression with Clinicopathological Features and Overall Survival in Endometrioid Endometrial Carcinoma
- Case Report: Primary endometrioid adenocarcinoma of the cervix and secondary cervical involvement by endometrial carcinoma: diagnostic pitfalls and an integrated approach based on two cases
- Complete loss of all mismatch repair protein expression in endometrioid carcinoma: A first case report of null phenotype induced by MLH1 hypermethylation and MSH2 somatic mutation
- Treatment patterns and prognostic factors of radiation-associated esophageal fistula in patients with esophageal squamous cell carcinoma: a retrospective cohort study
BibTeX
@article{adalı2026prognostic,
title = {{Prognostic Role of TP53 and ARID1A Mutations in Alcohol-Consuming Patients With Uterine Endometrioid Carcinoma}},
author = {Yasemin Adalı},
journal = {Applied Immunohistochemistry \& Molecular Morphology},
year = {2026},
month = jul,
doi = {10.1097/pai.0000000000001343},
url = {https://doi.org/10.1097/pai.0000000000001343},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Prognostic Role of TP53 and ARID1A Mutations in Alcohol-Consuming Patients With Uterine Endometrioid Carcinoma
AU - Yasemin Adalı
PY - 2026
DA - 2026/07/13
JO - Applied Immunohistochemistry & Molecular Morphology
DO - 10.1097/pai.0000000000001343
UR - https://doi.org/10.1097/pai.0000000000001343
AB - Uterine endometrioid carcinoma (UEC) is the most common subtype of endometrial cancer. This study aimed to investigate the prognostic relevance of TP53 and ARID1A mutations in alcohol-consuming UEC patients using publicly available TCGA data. A total of 207 UEC patients were identified from the TCGA CPTAC-3 project. Alcohol consumption status was extracted from self-reported clinical data. Patients were grouped into alcohol consumers and nonconsumers. Kaplan-Meier survival estimates and multivariable Cox proportional hazards models were used to evaluate the association between gene mutation status and overall survival, adjusted for age, stage, and grade. Sensitivity analyses excluded deaths within the first year. Out of 207 patients, 47 (22.7%) reported alcohol consumption. TP53 mutations were more prevalent in alcohol consumers compared with nonconsumers (36.2% vs. 21.3%, P=0.037). In the alcohol-consuming subgroup, patients with wild-type TP53 had significantly worse survival than those with TP53 mutations in sensitivity analysis (HR=2.85; 95% CI: 1.01-8.05; P=0.047). ARID1A wild-type status was associated with increased mortality risk compared with mutated ARID1A in adjusted models (HR=4.00; 95% CI: 1.45-11.01; P=0.007). No statistically significant survival differences were found for PTEN, PIK3CA, or KRAS mutations. TP53 and ARID1A mutation status may have prognostic relevance among alcohol-consuming patients with UEC. These findings suggest a possible gene-environment interaction in endometrial cancer and support the need for further validation through prospective studies.
SN - 1541-2016
SN - 1533-4058
ER -