Topographic structure and function of locus coeruleus noradrenaline neurons

@article{su2026topographic,
  title = {{Topographic structure and function of locus coeruleus noradrenaline neurons}},
  author = {Zhixiao Su and Polina Kosillo and Kanghoon Jung and Shuonan Chen and Mathew T. Summers and Alex T. Piet and Han Hou and Kenta M. Hagihara and Drew Friedmann and Olivia Ho-Shing and Matthew I. Becker and Thomas Chartrand and Xinxin Yin and Peter Grotz and Ella Hilton-VanOsdall and Margaret Lee and Rajvi Javeri and Samantha L. Black and Naveen D. Ouellette and Holly Myers and Judith Baka and Camilo Laiton-Bonadiez and Kaelin Wulf and John Rohde and Alessio Paolo Buccino and Cameron Arshadi and Di Wang and Sharmishtaa Seshamani and Sonya Vasquez and Carolyn M. Eng and Douglas R. Ollerenshaw and Nick Dee and Tamara Casper and Windy Ho and Matthew Jungert and Atlas Jordan and Elliot J Phillips and Anish Bhaswanth Chakka and Kamiliam Nasirova and Krista Blake and Audrey McCutcheon and Megan Koch and María Camila Vergara and Kimberly A. Smith and Tim Jarsky and Nicholas A. Lusk and Mara C.P. Rue and Xiaoyin Chen and Joshua H. Siegle and Adam K. Glaser and Brian Lee and Karel Svoboda and Yoh Isogai and Jayaram V. Chandrashekar and Jeremiah Y. Cohen},
  journal = {Nature},
  year = {2026},
  month = sep,
  doi = {10.1038/s41586-026-11026-0},
  url = {https://doi.org/10.1038/s41586-026-11026-0},
  note = {CC BY},
}

TY  - JOUR
TI  - Topographic structure and function of locus coeruleus noradrenaline neurons
AU  - Zhixiao Su
AU  - Polina Kosillo
AU  - Kanghoon Jung
AU  - Shuonan Chen
AU  - Mathew T. Summers
AU  - Alex T. Piet
AU  - Han Hou
AU  - Kenta M. Hagihara
AU  - Drew Friedmann
AU  - Olivia Ho-Shing
AU  - Matthew I. Becker
AU  - Thomas Chartrand
AU  - Xinxin Yin
AU  - Peter Grotz
AU  - Ella Hilton-VanOsdall
AU  - Margaret Lee
AU  - Rajvi Javeri
AU  - Samantha L. Black
AU  - Naveen D. Ouellette
AU  - Holly Myers
AU  - Judith Baka
AU  - Camilo Laiton-Bonadiez
AU  - Kaelin Wulf
AU  - John Rohde
AU  - Alessio Paolo Buccino
AU  - Cameron Arshadi
AU  - Di Wang
AU  - Sharmishtaa Seshamani
AU  - Sonya Vasquez
AU  - Carolyn M. Eng
AU  - Douglas R. Ollerenshaw
AU  - Nick Dee
AU  - Tamara Casper
AU  - Windy Ho
AU  - Matthew Jungert
AU  - Atlas Jordan
AU  - Elliot J Phillips
AU  - Anish Bhaswanth Chakka
AU  - Kamiliam Nasirova
AU  - Krista Blake
AU  - Audrey McCutcheon
AU  - Megan Koch
AU  - María Camila Vergara
AU  - Kimberly A. Smith
AU  - Tim Jarsky
AU  - Nicholas A. Lusk
AU  - Mara C.P. Rue
AU  - Xiaoyin Chen
AU  - Joshua H. Siegle
AU  - Adam K. Glaser
AU  - Brian Lee
AU  - Karel Svoboda
AU  - Yoh Isogai
AU  - Jayaram V. Chandrashekar
AU  - Jeremiah Y. Cohen
PY  - 2026
DA  - 2026/09/16
JO  - Nature
DO  - 10.1038/s41586-026-11026-0
UR  - https://doi.org/10.1038/s41586-026-11026-0
AB  - . Here we identified a relationship between the morphologies, gene expression and activity of noradrenergic neurons in locus coeruleus in mice. Axonal projections of individual neurons were extensive but largely confined to subsets of brain regions. Axonal projections and graded gene expression correlated with locations of cell bodies in locus coeruleus. In a behavioural task requiring continuous learning from actions, dorsal locus coeruleus neurons projecting to isocortex were activated when mice switched choices and by reward-prediction-error signals that drive learning. Background activity of neurons in ventral locus coeruleus was higher when mice ignored stimuli indicating potential reward availability. These observations reveal a topographically organized structure and function of a neurotransmitter system and show that it contains learning signals for flexible behaviour.
SN  - 0028-0836
SN  - 1476-4687
ER  -