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Peer-reviewedCC BY-NC-NDFASEB journal : official publication of the Federation of American Societies for Experimental Biology

Evidence for the Existence of Neural Stem-Like Cells in Adult Rodent Intrinsic Cardiac Nervous Ganglia.

  • Alice Jean1
  • Guenaelle Lizot1
  • Mathieu Gourmelon2,3
  • Fabrice Antigny2
  • Laetitia Cousin4
  • Michela Crotti4
  • Patricia Arnault4
  • Jocelyn Bescond1
  • Patrick Bois1
  • Bruno Constantin4
  • Valerie Coronas4
  • Aurelien Chatelier1,5
5 affiliations
  1. 1PReTI Laboratory, UR 24184, University of Poitiers, Poitiers, France.
  2. 2Université Paris-Saclay, INSERM, UMR_S 1358, Hypertension Pulmonaire: Physiopathologie and Innovation Thérapeutique (HPPIT), AP-HP, Hôpital Bicêtre, Hôpital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Plessis Robinson, France.
  3. 3Department of Preclinical Research, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, Le Plessis Robinson, France.
  4. 44CS, Laboratory Channels & Connexins in Cancers and Cell Stemness, UR 22751, CEDEX 09, University of Poitiers, Poitiers, France.
  5. 5Department of Medicine, Faculty of Medicine, CERVO Brain Research Centre, Université Laval, Quebec City, Quebec, Canada.
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Abstract

Cardiac function is modulated by the intrinsic cardiac nervous system (ICNS), which integrates autonomic signals and undergoes remodeling in pathological conditions. Here, we demonstrate that adult rodent ICNS ganglia harbor neural stem-like cells that proliferate in vitro, form neurospheres, self-renew, and generate neurons expressing βIII-tubulin and PGP 9.5. In vivo, cells expressing the stem cell marker SOX2 are detected within ICNS ganglia. Moreover, cardiac injury induced by monocrotaline increases the number of SOX2-positive cells expressing the cell cycle marker Ki67 and the number of EdU-incorporating, nestin-expressing cells within the ICNS. Together, our data provide the first evidence of neural stem-like cells in adult ICNS ganglia and suggest their potential role in cardiac neuroplasticity.

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Cite

BibTeXRIS
BibTeX
@article{jean2026evidence,
  title = {{Evidence for the Existence of Neural Stem-Like Cells in Adult Rodent Intrinsic Cardiac Nervous Ganglia.}},
  author = {Alice Jean and Guenaelle Lizot and Mathieu Gourmelon and Fabrice Antigny and Laetitia Cousin and Michela Crotti and Patricia Arnault and Jocelyn Bescond and Patrick Bois and Bruno Constantin and Valerie Coronas and Aurelien Chatelier},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year = {2026},
  month = oct,
  doi = {10.1096/fj.202601054r},
  url = {https://europepmc.org/article/MED/42952306},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Evidence for the Existence of Neural Stem-Like Cells in Adult Rodent Intrinsic Cardiac Nervous Ganglia.
AU  - Alice Jean
AU  - Guenaelle Lizot
AU  - Mathieu Gourmelon
AU  - Fabrice Antigny
AU  - Laetitia Cousin
AU  - Michela Crotti
AU  - Patricia Arnault
AU  - Jocelyn Bescond
AU  - Patrick Bois
AU  - Bruno Constantin
AU  - Valerie Coronas
AU  - Aurelien Chatelier
PY  - 2026
DA  - 2026/10/29
JO  - FASEB journal : official publication of the Federation of American Societies for Experimental Biology
DO  - 10.1096/fj.202601054r
UR  - https://europepmc.org/article/MED/42952306
AB  - Cardiac function is modulated by the intrinsic cardiac nervous system (ICNS), which integrates autonomic signals and undergoes remodeling in pathological conditions. Here, we demonstrate that adult rodent ICNS ganglia harbor neural stem-like cells that proliferate in vitro, form neurospheres, self-renew, and generate neurons expressing βIII-tubulin and PGP 9.5. In vivo, cells expressing the stem cell marker SOX2 are detected within ICNS ganglia. Moreover, cardiac injury induced by monocrotaline increases the number of SOX2-positive cells expressing the cell cycle marker Ki67 and the number of EdU-incorporating, nestin-expressing cells within the ICNS. Together, our data provide the first evidence of neural stem-like cells in adult ICNS ganglia and suggest their potential role in cardiac neuroplasticity.
SN  - 0892-6638
SN  - 1530-6860
ER  -