A liquid implant that grows into a stable scaffold in situ
Abstract
Endovascular embolization requires materials that can pass through narrow microcatheters yet form stable, conformal occlusions within irregular vascular lesions, but reconciling these competing requirements remains challenging. Here we report a wirelessly activated liquid precursor whose final architecture is constructed only after target localization. A gallium-based liquid metal containing iron microparticles and gas microcavities remains deformable, magnetically navigable, and retrievable before activation. Wireless induction heating activates the internal reactive microenvironment, coupling gas-driven microcavity growth with oxidative mineralization of newly generated gallium interfaces to form a porous, self-supporting scaffold. In aneurysm and arteriovenous malformation models, activation enabled durable occlusion, aneurysm-neck healing, and six-month stability in a porcine aneurysm model. These findings establish post-delivery construction as a strategy for creating stable therapeutic implants from minimally invasive liquid precursors.
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BibTeX
@misc{li2026liquid,
title = {{A liquid implant that grows into a stable scaffold in situ}},
author = {Wenqiang Li and Qichen Peng and Fuhong Wang and Zhentan Quan and Shengxiang Cai and Zhuoming Zhou and Jin Zhang and Ting Liu and Xuanping Xie and Lin Zhu and Bo Wang and Shuang Wang and Yuan An and Yingtong Zhou and Zirong Liu and Haohui Li and Songshen Li and Ben Wang and Xinjian Yang and Quanshui Zheng and Hongzhang Wang},
howpublished = {arXiv},
year = {2026},
month = nov,
doi = {10.48550/arxiv.2611.09961},
eprint = {2611.09961},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2611.09961},
}
RIS
TY - UNPB
TI - A liquid implant that grows into a stable scaffold in situ
AU - Wenqiang Li
AU - Qichen Peng
AU - Fuhong Wang
AU - Zhentan Quan
AU - Shengxiang Cai
AU - Zhuoming Zhou
AU - Jin Zhang
AU - Ting Liu
AU - Xuanping Xie
AU - Lin Zhu
AU - Bo Wang
AU - Shuang Wang
AU - Yuan An
AU - Yingtong Zhou
AU - Zirong Liu
AU - Haohui Li
AU - Songshen Li
AU - Ben Wang
AU - Xinjian Yang
AU - Quanshui Zheng
AU - Hongzhang Wang
PY - 2026
DA - 2026/11/01
PB - arXiv
DO - 10.48550/arxiv.2611.09961
UR - https://arxiv.org/abs/2611.09961
AB - Endovascular embolization requires materials that can pass through narrow microcatheters yet form stable, conformal occlusions within irregular vascular lesions, but reconciling these competing requirements remains challenging. Here we report a wirelessly activated liquid precursor whose final architecture is constructed only after target localization. A gallium-based liquid metal containing iron microparticles and gas microcavities remains deformable, magnetically navigable, and retrievable before activation. Wireless induction heating activates the internal reactive microenvironment, coupling gas-driven microcavity growth with oxidative mineralization of newly generated gallium interfaces to form a porous, self-supporting scaffold. In aneurysm and arteriovenous malformation models, activation enabled durable occlusion, aneurysm-neck healing, and six-month stability in a porcine aneurysm model. These findings establish post-delivery construction as a strategy for creating stable therapeutic implants from minimally invasive liquid precursors.
ER -