Synthesis of Chiral Gold Nanostructures on Gold‐Coral‐Coated Transparent Conductive Oxide Substrates via [AuCl4]– and Cysteine Interactions for Enhanced Chiral Sensing
6 affiliations
- 1Comprehensive Research Organization Waseda University Tokyo Japan
- 2Faculty of Science and Engineering Waseda University Tokyo Japan
- 3International Center for Materials Nanoarchitectonics (WPI‐MANA) National Institute for Materials Science (NIMS) Tsukuba Ibaraki Japan
- 4Department of Materials Science and Engineering School of Engineering Nagoya University Nagoya Japan
- 5Australian Institute for Bioengineering and Nanotechnology (AIBN) The University of Queensland (UQ) Brisbane QLD Australia
- 6Research Organization for Nano & Life Innovation Waseda University Tokyo Japan
Abstract
Chirality appears in many molecules, crystals, and nanostructures and plays an important role in their physicochemical and biological functions. Because biological systems exhibit a chiral bias, they respond differently to each chiral enantiomer. Therefore, it is very important to develop methods or devices that can discriminate the enantiomers easily. Metallic nanostructures such as nanoparticles, nanorods, and mesoporous films exhibit significantly enhanced optical responses due to localized surface plasmon resonance. The optical properties of these nanostructures are highly dependent on their size, shape, and elemental composition, all of which can be precisely controlled through optimized chemical synthesis. In this study, we developed a hierarchical nanostructure of chiral Au nanostructures on Au coral structures, which were synthesized on transparent conductive oxide substrates using only electrochemical techniques. By considering both the substitution of chloride ions in [AuCl4]− with cysteine in the electrolyte solution and the subsequent reduction of the Au(III) complexes, we successfully controlled the morphology of the Au nanostructures, which exhibit circular dichroism. Furthermore, we explored the potential for chiral discrimination using these substrates. The hierarchical chiral Au nanostructures on Au coral structures enhanced the SERS intensity relative to Au corals alone and produced enantiomer‐dependent SERS responses for L‐ and D‐phenylalanine, demonstrating their potential for chiral discrimination.
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BibTeX
@article{nakagawa2026synthesis,
title = {{Synthesis of Chiral Gold Nanostructures on Gold‐Coral‐Coated Transparent Conductive Oxide Substrates via [AuCl4]– and Cysteine Interactions for Enhanced Chiral Sensing}},
author = {Kenta Nakagawa and Junhe Wang and Tianji Zhang and Yuta Shiga and Olga Guselnikova and Takuya Nakanishi and Yusuke Yamauchi and Toru Asahi},
journal = {Small (Weinheim an Der Bergstrasse, Germany)},
year = {2026},
month = sep,
doi = {10.1002/smll.75471},
url = {https://doi.org/10.1002/smll.75471},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Synthesis of Chiral Gold Nanostructures on Gold‐Coral‐Coated Transparent Conductive Oxide Substrates via [AuCl4]– and Cysteine Interactions for Enhanced Chiral Sensing
AU - Kenta Nakagawa
AU - Junhe Wang
AU - Tianji Zhang
AU - Yuta Shiga
AU - Olga Guselnikova
AU - Takuya Nakanishi
AU - Yusuke Yamauchi
AU - Toru Asahi
PY - 2026
DA - 2026/09/03
JO - Small (Weinheim an Der Bergstrasse, Germany)
DO - 10.1002/smll.75471
UR - https://doi.org/10.1002/smll.75471
AB - Chirality appears in many molecules, crystals, and nanostructures and plays an important role in their physicochemical and biological functions. Because biological systems exhibit a chiral bias, they respond differently to each chiral enantiomer. Therefore, it is very important to develop methods or devices that can discriminate the enantiomers easily. Metallic nanostructures such as nanoparticles, nanorods, and mesoporous films exhibit significantly enhanced optical responses due to localized surface plasmon resonance. The optical properties of these nanostructures are highly dependent on their size, shape, and elemental composition, all of which can be precisely controlled through optimized chemical synthesis. In this study, we developed a hierarchical nanostructure of chiral Au nanostructures on Au coral structures, which were synthesized on transparent conductive oxide substrates using only electrochemical techniques. By considering both the substitution of chloride ions in [AuCl4]− with cysteine in the electrolyte solution and the subsequent reduction of the Au(III) complexes, we successfully controlled the morphology of the Au nanostructures, which exhibit circular dichroism. Furthermore, we explored the potential for chiral discrimination using these substrates. The hierarchical chiral Au nanostructures on Au coral structures enhanced the SERS intensity relative to Au corals alone and produced enantiomer‐dependent SERS responses for L‐ and D‐phenylalanine, demonstrating their potential for chiral discrimination.
SN - 1613-6810
SN - 1613-6829
ER -