Microenvironmental-Regulated Chondroitin Sulfate Nanomicelles for Inhibition of Breast Cancer Drug Resistance and Metastasis
6 affiliations
- 1Weifang University of Science and Technology , , ,
- 2Weifang People’s Hospital , , ,
- 3Weifa ng People’s Hospital , , ,
- 4Jining University , , , ,
- 5Luoyang Normal University , , ,
- 6Gaomi People’s Hospital , , ,
Abstract
Tumor microenvironment is closely involved in breast cancer progression and metastatic spread. Therefore, it is essential to develop a combination therapy to suppress tumor progression by regulating TME. Herein, Ru486-loaded doxorubicin (DOX)–chondroitin sulfate (chondroitin sulfate) nanomicelles (R/D-CS) were prepared for combined delivery. A “MCF-7 + MRC-5” dual-cell model and “4T1 + NIH-3T3” cell-bearing mouse model were established to recapitulate TME in vitro and in vivo, respectively. Interestingly, R/D-CS nanomicelles internalized cancer-associated fibroblasts and tumor cells and reduced tumor proliferation and migration markedly by downregulating expression of P-gp, vimentin, and CXCR4. Moreover, the in vivo antitumor studies were performed on a tumor-bearing mouse model, R/D-CS nanomicelles showed stronger antiproliferative and antimetastatic effects. Overall, the combination therapy based on R/D-CS nanomicelles was potent for breast cancer treatment.
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BibTeX
@article{wu2026microenvironmentalregulated,
title = {{Microenvironmental-Regulated Chondroitin Sulfate Nanomicelles for Inhibition of Breast Cancer Drug Resistance and Metastasis}},
author = {Jingliang Wu and Zhen Guo and Na Li and Di Wang and Shujie Sun and Bo Zhang and Zhipeng Li and Pei Zhang and Yueliang Cao and Qian Xu},
journal = {ACS Omega},
year = {2026},
month = oct,
doi = {10.1021/acsomega.5c05935},
url = {https://pubs.acs.org/acsodf/article/11/42/64339/5450558/Microenvironmental-Regulated-Chondroitin-Sulfate},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Microenvironmental-Regulated Chondroitin Sulfate Nanomicelles for Inhibition of Breast Cancer Drug Resistance and Metastasis
AU - Jingliang Wu
AU - Zhen Guo
AU - Na Li
AU - Di Wang
AU - Shujie Sun
AU - Bo Zhang
AU - Zhipeng Li
AU - Pei Zhang
AU - Yueliang Cao
AU - Qian Xu
PY - 2026
DA - 2026/10/13
JO - ACS Omega
DO - 10.1021/acsomega.5c05935
UR - https://pubs.acs.org/acsodf/article/11/42/64339/5450558/Microenvironmental-Regulated-Chondroitin-Sulfate
AB - Tumor microenvironment is closely involved in breast cancer progression and metastatic spread. Therefore, it is essential to develop a combination therapy to suppress tumor progression by regulating TME. Herein, Ru486-loaded doxorubicin (DOX)–chondroitin sulfate (chondroitin sulfate) nanomicelles (R/D-CS) were prepared for combined delivery. A “MCF-7 + MRC-5” dual-cell model and “4T1 + NIH-3T3” cell-bearing mouse model were established to recapitulate TME in vitro and in vivo, respectively. Interestingly, R/D-CS nanomicelles internalized cancer-associated fibroblasts and tumor cells and reduced tumor proliferation and migration markedly by downregulating expression of P-gp, vimentin, and CXCR4. Moreover, the in vivo antitumor studies were performed on a tumor-bearing mouse model, R/D-CS nanomicelles showed stronger antiproliferative and antimetastatic effects. Overall, the combination therapy based on R/D-CS nanomicelles was potent for breast cancer treatment.
SN - 2470-1343
ER -