Effects of Wall-broken yeast powder on gut microbiota and serum metabolome in captive forest musk deer (Moschus bere-zovskii)
- 1College of Smart Agriculture, Chongqing University of Arts and Sciences, Chongqing, China
- 2Chongqing Institute of Medicinal Plant Cultivation, Chongqing University of Chinese Medicine, Chongqing, China
- 3Department of Ophthalmology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China
Abstract
Forest musk deer (Moschus berezovskii), a nationally protected species, has experienced a rapid population decline, highlighting the need to improve captive breeding strategies. Captive individuals are more susceptible to gastrointestinal disorders than wild individuals, making dietary regulation important for intestinal health. Wall-broken yeast (BWY) powder, has attracted increasing attention as a functional feed additive due to its potential roles in regulating intestinal health, microbial composition, and host metabolism. This study evaluated the effects of wall-broken yeast powder on gut microbiota, and serum metabolome in forest musk deer. Fourteen healthy male forest musk deer aged 4.5 years, were randomly assigned to two groups (n = 7). The CK group was fed a basal diet, whereas the BWY group was fed the basal diet supplemented with 15 g/kg DM wall-broken yeast powder for a 7 d adaptation period and a 30 d experimental period. 16S rDNA sequencing showed that BWY supplementation altered gut microbial community structure based on β-diversity analysis, with Ruminobacter, UCG-005, and Bacteroides showing increased relative abundance in the BWY group. Serum metabolomics identified 69 differential metabolites between the CK and BWY groups (VIP > 1 and P < 0.05), with upregulated metabolites mainly enriched in amino acids and their metabolites, hormones and hormone-related substances, and glycerophospholipids. Key metabolic pathways included ABC transporters, glycerophospholipid metabolism, phenylalanine metabolism, and β-alanine metabolism. Correlation analysis showed that Prevotellaceae_UCG-004 was positively associated with serum salidroside levels, whereas Ruminobacter was positively correlated with quinolinic acid, Lys-Gly, Gly-Lys, and Cyclo(Pro-Leu) levels (P < 0.05). Overall, wall-broken yeast powder supplementation may modulate gut microbial composition and affect amino acid metabolism in forest musk deer.
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BibTeX
@article{wu2026effects,
title = {{Effects of Wall-broken yeast powder on gut microbiota and serum metabolome in captive forest musk deer (Moschus bere-zovskii)}},
author = {Yongjiang Wu and Tianjun Chen and Zaixiang Ying and Shan Xie and Wei Su and Ningqian Tan and Mingcheng Cai and Dejun Zeng and Chenglu Zhang and Qiuping Huang and Siqi Peng and Zhonggui Jiang and Qinlin Yang},
journal = {Frontiers in Veterinary Science},
year = {2026},
month = oct,
doi = {10.3389/fvets.2026.1978027},
url = {https://doi.org/10.3389/fvets.2026.1978027},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Effects of Wall-broken yeast powder on gut microbiota and serum metabolome in captive forest musk deer (Moschus bere-zovskii)
AU - Yongjiang Wu
AU - Tianjun Chen
AU - Zaixiang Ying
AU - Shan Xie
AU - Wei Su
AU - Ningqian Tan
AU - Mingcheng Cai
AU - Dejun Zeng
AU - Chenglu Zhang
AU - Qiuping Huang
AU - Siqi Peng
AU - Zhonggui Jiang
AU - Qinlin Yang
PY - 2026
DA - 2026/10/22
JO - Frontiers in Veterinary Science
DO - 10.3389/fvets.2026.1978027
UR - https://doi.org/10.3389/fvets.2026.1978027
AB - Forest musk deer (Moschus berezovskii), a nationally protected species, has experienced a rapid population decline, highlighting the need to improve captive breeding strategies. Captive individuals are more susceptible to gastrointestinal disorders than wild individuals, making dietary regulation important for intestinal health. Wall-broken yeast (BWY) powder, has attracted increasing attention as a functional feed additive due to its potential roles in regulating intestinal health, microbial composition, and host metabolism. This study evaluated the effects of wall-broken yeast powder on gut microbiota, and serum metabolome in forest musk deer. Fourteen healthy male forest musk deer aged 4.5 years, were randomly assigned to two groups (n = 7). The CK group was fed a basal diet, whereas the BWY group was fed the basal diet supplemented with 15 g/kg DM wall-broken yeast powder for a 7 d adaptation period and a 30 d experimental period. 16S rDNA sequencing showed that BWY supplementation altered gut microbial community structure based on β-diversity analysis, with Ruminobacter, UCG-005, and Bacteroides showing increased relative abundance in the BWY group. Serum metabolomics identified 69 differential metabolites between the CK and BWY groups (VIP > 1 and P < 0.05), with upregulated metabolites mainly enriched in amino acids and their metabolites, hormones and hormone-related substances, and glycerophospholipids. Key metabolic pathways included ABC transporters, glycerophospholipid metabolism, phenylalanine metabolism, and β-alanine metabolism. Correlation analysis showed that Prevotellaceae_UCG-004 was positively associated with serum salidroside levels, whereas Ruminobacter was positively correlated with quinolinic acid, Lys-Gly, Gly-Lys, and Cyclo(Pro-Leu) levels (P < 0.05). Overall, wall-broken yeast powder supplementation may modulate gut microbial composition and affect amino acid metabolism in forest musk deer.
SN - 2297-1769
ER -