SOX7 Is Required for Muscle Satellite Cell Development and Maintenance
Abstract
Satellite cells are skeletal-muscle-specific stem cells that are activated by injury to proliferate, differentiate, and fuse to enable repair. SOX7, a member of the SRY-related HMG-box family of transcription factors is expressed in quiescent satellite cells. To elucidate SOX7 function in skeletal muscle, we knocked down Sox7 expression in embryonic stem cells and primary myoblasts and generated a conditional knockout mouse in which Sox7 is excised in PAX3 + cells. Loss of Sox7 in embryonic stem cells reduced Pax3 and Pax7 expression. In vivo , conditional knockdown of Sox7 reduced the satellite cell population from birth, reduced myofiber caliber, and impaired regeneration after acute injury. Although Sox7 -deficient primary myoblasts differentiated normally, impaired myoblast fusion and increased sensitivity to apoptosis in culture and in vivo were observed. Taken together, these results indicate that SOX7 is dispensable for myogenesis but is necessary to promote satellite cell development and survival.
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BibTeX
@article{rajgara2026sox7,
title = {{SOX7 Is Required for Muscle Satellite Cell Development and Maintenance}},
author = {Rashida Rajgara and Neena Lala-Tabbert and François Marchildon and Émilie Lamarche and Jennifer Macdonald and Daryl Scott and Alexandre Blais and Ilona Skerjanc and Nadine Wiper-Bergeron},
journal = {Stem Cell Reports},
year = {2026},
month = oct,
doi = {10.1016/j.stemcr.2017.08.014},
url = {https://hal.science/hal-05794899v1},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - SOX7 Is Required for Muscle Satellite Cell Development and Maintenance
AU - Rashida Rajgara
AU - Neena Lala-Tabbert
AU - François Marchildon
AU - Émilie Lamarche
AU - Jennifer Macdonald
AU - Daryl Scott
AU - Alexandre Blais
AU - Ilona Skerjanc
AU - Nadine Wiper-Bergeron
PY - 2026
DA - 2026/10/12
JO - Stem Cell Reports
DO - 10.1016/j.stemcr.2017.08.014
UR - https://hal.science/hal-05794899v1
AB - Satellite cells are skeletal-muscle-specific stem cells that are activated by injury to proliferate, differentiate, and fuse to enable repair. SOX7, a member of the SRY-related HMG-box family of transcription factors is expressed in quiescent satellite cells. To elucidate SOX7 function in skeletal muscle, we knocked down Sox7 expression in embryonic stem cells and primary myoblasts and generated a conditional knockout mouse in which Sox7 is excised in PAX3 + cells. Loss of Sox7 in embryonic stem cells reduced Pax3 and Pax7 expression. In vivo , conditional knockdown of Sox7 reduced the satellite cell population from birth, reduced myofiber caliber, and impaired regeneration after acute injury. Although Sox7 -deficient primary myoblasts differentiated normally, impaired myoblast fusion and increased sensitivity to apoptosis in culture and in vivo were observed. Taken together, these results indicate that SOX7 is dispensable for myogenesis but is necessary to promote satellite cell development and survival.
SN - 2213-6711
ER -