Recurrent venous thromboembolism despite natural cycle frozen embryo transfer in a woman with a history of pregnancy-related venous thromboembolism: A case report.
- 1Department of Obstetrics and Gynecology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Abstract
Pregnancy-associated venous thromboembolism (VTE) is a major cause of maternal morbidity and mortality. Pregnancies achieved by in vitro fertilization carry an increased risk of VTE, particularly during early gestation. A 33-year-old woman developed deep vein thrombosis during late pregnancy in her first spontaneous conception despite no identifiable thrombophilia. During a subsequent pregnancy achieved by natural cycle frozen embryo transfer, which was selected to avoid exogenous estrogen exposure and potentially reduce the thrombotic risk compared with hormone replacement cycles, she developed recurrent VTE at 8 weeks of gestation. Anticoagulation therapy was initiated, and an inferior vena cava (IVC) filter was placed in late pregnancy because of persistent thrombus and delivery-related risk. A cesarean section was successfully performed, and the IVC filter was removed postpartum after regression of the thrombus. Although natural cycle frozen embryo transfer may reduce the thrombotic risk compared with hormone replacement cycles, it does not eliminate the risk of recurrent VTE in women with a history of pregnancy-associated thrombosis. Early initiation of anticoagulation and careful peripartum management, including selective use of IVC filters, are essential in high-risk patients.
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BibTeX
@article{sato2026recurrent,
title = {{Recurrent venous thromboembolism despite natural cycle frozen embryo transfer in a woman with a history of pregnancy-related venous thromboembolism: A case report.}},
author = {Yutaro Sato and Eiji Nishio and Shota Oikawa and Sana Odake and Miho Ishikawa and Eriko Sakakibara and Kiriko Kotani and Hikari Yoshizawa and Hironori Miyamura and Haruki Nishizawa and Iori Kisu},
journal = {Fujita medical journal},
year = {2026},
month = sep,
doi = {10.20407/fmj.2026-002},
url = {https://europepmc.org/article/MED/42969006},
note = {CC BY},
}
RIS
TY - JOUR
TI - Recurrent venous thromboembolism despite natural cycle frozen embryo transfer in a woman with a history of pregnancy-related venous thromboembolism: A case report.
AU - Yutaro Sato
AU - Eiji Nishio
AU - Shota Oikawa
AU - Sana Odake
AU - Miho Ishikawa
AU - Eriko Sakakibara
AU - Kiriko Kotani
AU - Hikari Yoshizawa
AU - Hironori Miyamura
AU - Haruki Nishizawa
AU - Iori Kisu
PY - 2026
DA - 2026/09/25
JO - Fujita medical journal
DO - 10.20407/fmj.2026-002
UR - https://europepmc.org/article/MED/42969006
AB - Pregnancy-associated venous thromboembolism (VTE) is a major cause of maternal morbidity and mortality. Pregnancies achieved by in vitro fertilization carry an increased risk of VTE, particularly during early gestation. A 33-year-old woman developed deep vein thrombosis during late pregnancy in her first spontaneous conception despite no identifiable thrombophilia. During a subsequent pregnancy achieved by natural cycle frozen embryo transfer, which was selected to avoid exogenous estrogen exposure and potentially reduce the thrombotic risk compared with hormone replacement cycles, she developed recurrent VTE at 8 weeks of gestation. Anticoagulation therapy was initiated, and an inferior vena cava (IVC) filter was placed in late pregnancy because of persistent thrombus and delivery-related risk. A cesarean section was successfully performed, and the IVC filter was removed postpartum after regression of the thrombus. Although natural cycle frozen embryo transfer may reduce the thrombotic risk compared with hormone replacement cycles, it does not eliminate the risk of recurrent VTE in women with a history of pregnancy-associated thrombosis. Early initiation of anticoagulation and careful peripartum management, including selective use of IVC filters, are essential in high-risk patients.
SN - 2189-7247
SN - 2189-7255
ER -