Neuron type-specific translatomes in dorsal hippocampus during early memory consolidation
- 1Center for Neural Science, New York University, New York City, NY, USA
- 2Department of Molecular Biology, Massachusetts General Hospital, Harvard University, Boston, MA, USA
- 3Center for Neural Science, New York University, New York City, NY, USA. [email protected]
Abstract
Long-term memory consolidation is a dynamic process that requires a heterogeneous ensemble of neurons, each with a highly specialized molecular signature. Considerable effort has been devoted to identifying molecular changes that accompany the process of consolidation, but mostly hours or days after training, when memory consolidation is already complete. Studies have shown that protein synthesis is elevated during the early stages of consolidation, but how this increase impacts neuronal function remains unclear. We hypothesize that mRNAs translated during the early stages of consolidation could provide information on how diverse neurons involved in memory formation restructure their molecular signatures to support memory. Here, we generate a landscape of the translatome of three neuron types in the dorsal hippocampus during the first hour of contextual memory consolidation. Our results reveal that translation programs associated with consolidation are different among neurons, fueling the reconfiguration of specific biological processes. We further demonstrate the patterned translation of mRNAs in different neuron types during consolidation is explained by features hard-coded in the mRNA sequence, suggesting ubiquitous mechanisms controlling activity-induced neuronal translation. Altogether, our work uncovers previously unknown mechanisms controlling activity-induced translation in neurons and provides a large, readily available resource for scientists interested in the role of memory formation in health and disease.
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BibTeX
@article{oliveira2026neuron,
title = {{Neuron type-specific translatomes in dorsal hippocampus during early memory consolidation}},
author = {Mauricio Martins Oliveira and Olivia Mosto and Robert Carney and Wendy J. Liu and Maggie Mamcarz and Emmanuel Makinde and Emily H. Lu and Karen San Agustin Ruiz and Carson C. Schultz and Catherine Leckie and Thomas James Carew and Eric Klann},
journal = {Nature Communications},
year = {2026},
month = jun,
doi = {10.1038/s41467-026-74455-5},
url = {https://doi.org/10.1038/s41467-026-74455-5},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Neuron type-specific translatomes in dorsal hippocampus during early memory consolidation
AU - Mauricio Martins Oliveira
AU - Olivia Mosto
AU - Robert Carney
AU - Wendy J. Liu
AU - Maggie Mamcarz
AU - Emmanuel Makinde
AU - Emily H. Lu
AU - Karen San Agustin Ruiz
AU - Carson C. Schultz
AU - Catherine Leckie
AU - Thomas James Carew
AU - Eric Klann
PY - 2026
DA - 2026/06/23
JO - Nature Communications
DO - 10.1038/s41467-026-74455-5
UR - https://doi.org/10.1038/s41467-026-74455-5
AB - Long-term memory consolidation is a dynamic process that requires a heterogeneous ensemble of neurons, each with a highly specialized molecular signature. Considerable effort has been devoted to identifying molecular changes that accompany the process of consolidation, but mostly hours or days after training, when memory consolidation is already complete. Studies have shown that protein synthesis is elevated during the early stages of consolidation, but how this increase impacts neuronal function remains unclear. We hypothesize that mRNAs translated during the early stages of consolidation could provide information on how diverse neurons involved in memory formation restructure their molecular signatures to support memory. Here, we generate a landscape of the translatome of three neuron types in the dorsal hippocampus during the first hour of contextual memory consolidation. Our results reveal that translation programs associated with consolidation are different among neurons, fueling the reconfiguration of specific biological processes. We further demonstrate the patterned translation of mRNAs in different neuron types during consolidation is explained by features hard-coded in the mRNA sequence, suggesting ubiquitous mechanisms controlling activity-induced neuronal translation. Altogether, our work uncovers previously unknown mechanisms controlling activity-induced translation in neurons and provides a large, readily available resource for scientists interested in the role of memory formation in health and disease.
SN - 2041-1723
ER -