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Peer-reviewedCC BYJournal of agricultural and food chemistry

Integrative Multi-Omics Reveals Tissue-Specific Postharvest Changes in Blueberry Fruit.

  • Molla Fentie Mengist1
  • Romit Seth2
  • Massimo Iorizzo2,3
  1. 1Agricultural Research Station, Virginia State University, Petersburg, Virginia23806, United States.
  2. 2Plants for Human Health Institute, North Carolina State University, Kannapolis, North Carolina28081, United States.
  3. 3Department of Horticultural Science, North Carolina State University, Raleigh, North Carolina27607, United States.
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Abstract

Postharvest cold storage is essential for maintaining blueberry fruit quality, yet the molecular basis of tissue-specific responses during storage remains poorly understood. Here, we integrated widely targeted metabolomics and transcriptomics to characterize peel and pulp responses during 6 weeks of storage at 4 °C. Metabolomic profiles revealed pronounced tissue specialization, with peel enriched in flavonoids, terpenoids, and phenylpropanoid-derived metabolites, whereas pulp accumulated amino acids and other primary metabolites. In contrast, transcriptomic variation was dominated by storage, indicating a largely conserved response across tissues. Multi-omics analyses using DIABLO, MOFA2, and network analysis identified 65 genes and 58 metabolites associated with storage-related and tissue-specific variation. These analyses highlighted jasmonate- and oxylipin-associated pathways, antioxidant responses, membrane lipid remodeling, and phenylpropanoid metabolism, alongside reduced expression of aquaporins and cell wall-modifying genes. Overall, these findings provide a systems-level view of blueberry storage responses and identify candidate molecular processes associated with postharvest quality and storage performance.

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Cite

BibTeXRIS
BibTeX
@article{mengist2026integrative,
  title = {{Integrative Multi-Omics Reveals Tissue-Specific Postharvest Changes in Blueberry Fruit.}},
  author = {Molla Fentie Mengist and Romit Seth and Massimo Iorizzo},
  journal = {Journal of agricultural and food chemistry},
  year = {2026},
  month = oct,
  doi = {10.1021/acs.jafc.6c13073},
  url = {https://europepmc.org/article/MED/42904962},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Integrative Multi-Omics Reveals Tissue-Specific Postharvest Changes in Blueberry Fruit.
AU  - Molla Fentie Mengist
AU  - Romit Seth
AU  - Massimo Iorizzo
PY  - 2026
DA  - 2026/10/01
JO  - Journal of agricultural and food chemistry
DO  - 10.1021/acs.jafc.6c13073
UR  - https://europepmc.org/article/MED/42904962
AB  - Postharvest cold storage is essential for maintaining blueberry fruit quality, yet the molecular basis of tissue-specific responses during storage remains poorly understood. Here, we integrated widely targeted metabolomics and transcriptomics to characterize peel and pulp responses during 6 weeks of storage at 4 °C. Metabolomic profiles revealed pronounced tissue specialization, with peel enriched in flavonoids, terpenoids, and phenylpropanoid-derived metabolites, whereas pulp accumulated amino acids and other primary metabolites. In contrast, transcriptomic variation was dominated by storage, indicating a largely conserved response across tissues. Multi-omics analyses using DIABLO, MOFA2, and network analysis identified 65 genes and 58 metabolites associated with storage-related and tissue-specific variation. These analyses highlighted jasmonate- and oxylipin-associated pathways, antioxidant responses, membrane lipid remodeling, and phenylpropanoid metabolism, alongside reduced expression of aquaporins and cell wall-modifying genes. Overall, these findings provide a systems-level view of blueberry storage responses and identify candidate molecular processes associated with postharvest quality and storage performance.
SN  - 0021-8561
SN  - 1520-5118
ER  -