Mitochondrial dynamics resolve physical-social tensions and challenges through adaptable multi-objective optimisation
- 1University of Bergen
Abstract
Complex biological behaviours often emerge when a system is faced with mutually incompatible priorities. In such situations, the field of multi-objective optimisation can provide an informative and predictive theoretical foundation for biology. Here we adopt this paradigm in exploring the rich dynamic behaviour of mitochondria inside cells. Using plant cells as a model system, we use physical modelling to characterise the "morphospace" of possible mitochondrial behaviours, and single-cell microscopy with video analysis and network modelling to characterise collective mitochondrial dynamics. We show that wildtype Arabidopsis mitochondrial dynamics near-optimally resolve a tradeoff between maintaining physical spacing and supporting biomolecular exchange. With existing and new experimental data, we show that these dynamics adapt under mutational and chemical challenges to support a rebalanced, but still near-optimal, resolution to this tradeoff under different densities of the mitochondrial population. We also show how an assumption of multi-objective optimisation supports inference of biological mechanisms before any data are observed, and discuss the potential of this multi-objective optimisation paradigm to form a broader theoretical framework of spatial cell biology.
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BibTeX
@misc{chustecki2026mitochondrial,
title = {{Mitochondrial dynamics resolve physical-social tensions and challenges through adaptable multi-objective optimisation}},
author = {J. Chustecki and I. Johnston},
howpublished = {bioRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.22.753427},
url = {https://www.biorxiv.org/content/10.64898/2026.09.22.753427v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Mitochondrial dynamics resolve physical-social tensions and challenges through adaptable multi-objective optimisation
AU - J. Chustecki
AU - I. Johnston
PY - 2026
DA - 2026/09/22
PB - bioRxiv
DO - 10.64898/2026.09.22.753427
UR - https://www.biorxiv.org/content/10.64898/2026.09.22.753427v1
AB - Complex biological behaviours often emerge when a system is faced with mutually incompatible priorities. In such situations, the field of multi-objective optimisation can provide an informative and predictive theoretical foundation for biology. Here we adopt this paradigm in exploring the rich dynamic behaviour of mitochondria inside cells. Using plant cells as a model system, we use physical modelling to characterise the "morphospace" of possible mitochondrial behaviours, and single-cell microscopy with video analysis and network modelling to characterise collective mitochondrial dynamics. We show that wildtype Arabidopsis mitochondrial dynamics near-optimally resolve a tradeoff between maintaining physical spacing and supporting biomolecular exchange. With existing and new experimental data, we show that these dynamics adapt under mutational and chemical challenges to support a rebalanced, but still near-optimal, resolution to this tradeoff under different densities of the mitochondrial population. We also show how an assumption of multi-objective optimisation supports inference of biological mechanisms before any data are observed, and discuss the potential of this multi-objective optimisation paradigm to form a broader theoretical framework of spatial cell biology.
ER -