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Peer-reviewedCC BY-NC-ND 4.0IDCases

A fatal case of cerebral scedosporiosis caused by Scedosporium boydii in a kidney transplant recipient: A case report and literature review

  • Mohammadreza Ardalan1
  • Parviz Hassanpour2
  • Farahnoosh Farnood3
  • Hossein Samadi Kafil4
  • Aydin Vaez5
  • Hamid Morovati6,7
  • Sanam Nami6
7 affiliations
  1. 1Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5Department of Infectious Disease, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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Abstract

Invasive opportunistic fungal infections are rare but devastating complications in solid organ transplant recipients, often associated with delayed diagnosis and high mortality. Among these, infections caused by Scedosporium species pose significant therapeutic challenges due to intrinsic antifungal resistance. We report a fatal case of cerebral scedosporiosis caused by Scedosporium boydii in a 52-year-old kidney transplant recipient with systemic lupus erythematosus. Following augmented immunosuppression therapy for suspected acute rejection, the patient developed persistent fever, neurological deterioration, and seizures. Neuroimaging revealed a hemorrhagic periventricular brain lesion, and the diagnosis was confirmed by mycological culture and internal transcribed spacer sequencing. Despite antifungal therapy with liposomal amphotericin B and neurosurgical intervention, the patient died. This case highlights the fulminant course of central nervous system scedosporiosis, the diagnostic challenges in transplant recipients, and the limited efficacy of the current treatment options.

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Cite

BibTeXRIS
BibTeX
@article{ardalan2026fatal,
  title = {{A fatal case of cerebral scedosporiosis caused by Scedosporium boydii in a kidney transplant recipient: A case report and literature review}},
  author = {Mohammadreza Ardalan and Parviz Hassanpour and Farahnoosh Farnood and Hossein Samadi Kafil and Aydin Vaez and Hamid Morovati and Sanam Nami},
  journal = {IDCases},
  year = {2026},
  month = oct,
  doi = {10.1016/j.idcr.2026.e02794},
  url = {https://doi.org/10.1016/j.idcr.2026.e02794},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - A fatal case of cerebral scedosporiosis caused by Scedosporium boydii in a kidney transplant recipient: A case report and literature review
AU  - Mohammadreza Ardalan
AU  - Parviz Hassanpour
AU  - Farahnoosh Farnood
AU  - Hossein Samadi Kafil
AU  - Aydin Vaez
AU  - Hamid Morovati
AU  - Sanam Nami
PY  - 2026
DA  - 2026/10/14
JO  - IDCases
DO  - 10.1016/j.idcr.2026.e02794
UR  - https://doi.org/10.1016/j.idcr.2026.e02794
AB  - Invasive opportunistic fungal infections are rare but devastating complications in solid organ transplant recipients, often associated with delayed diagnosis and high mortality. Among these, infections caused by Scedosporium species pose significant therapeutic challenges due to intrinsic antifungal resistance. We report a fatal case of cerebral scedosporiosis caused by Scedosporium boydii in a 52-year-old kidney transplant recipient with systemic lupus erythematosus. Following augmented immunosuppression therapy for suspected acute rejection, the patient developed persistent fever, neurological deterioration, and seizures. Neuroimaging revealed a hemorrhagic periventricular brain lesion, and the diagnosis was confirmed by mycological culture and internal transcribed spacer sequencing. Despite antifungal therapy with liposomal amphotericin B and neurosurgical intervention, the patient died. This case highlights the fulminant course of central nervous system scedosporiosis, the diagnostic challenges in transplant recipients, and the limited efficacy of the current treatment options.
SN  - 2214-2509
ER  -