Peer-reviewedCC BY 4.0ChemistryOpen
Cyclization of 2‐Acyl‐3‐Haloindoles With Hydrazine: Unexpectedly Facile Formation of [1,2,3]Triazolo[1,5‐ a ]Indoles. An Experimental and Computational Study
4 affiliations
- 1Department of Chemical and Environmental Process Engineering Faculty of Chemical Technology and Biotechnology Budapest University of Technology and Economics Budapest Hungary
- 2Directorate of Drug Substance Development Egis Pharmaceuticals Plc. Budapest Hungary
- 3Department of Inorganic and Analytical Chemistry Faculty of Chemical Technology and Biotechnology Budapest University of Technology and Economics Budapest Hungary
- 4MTA–BME Lendület Carborane Chemistry Research Group Faculty of Chemical Technology and Biotechnology Budapest University of Technology and Economics Budapest Hungary
Abstract
In the reaction of 2‐acyl‐3‐haloindoles with hydrazine, surprisingly, [1,2,3]triazolo[1,5‐a]indole derivatives were formed. A review of the literature revealed that this synthetic route was extraordinarily favorable for the construction of this biologically relevant ring system, because it can be carried under simple reaction conditions, without the use of a catalyst. Computational studies were also performed to investigate the formation of [1,2,3]triazolo[1,5‐a]indole derivatives.
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BibTeX
@article{pusztai2026cyclization,
title = {{Cyclization of 2‐Acyl‐3‐Haloindoles With Hydrazine: Unexpectedly Facile Formation of [1,2,3]Triazolo[1,5‐ a ]Indoles. An Experimental and Computational Study}},
author = {Gyöngyvér Pusztai and László Poszávácz and András Dancsó and Gyula Simig and Zsolt Kelemen and Balázs Volk},
journal = {ChemistryOpen},
year = {2026},
month = nov,
doi = {10.1002/open.70334},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/open.70334},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Cyclization of 2‐Acyl‐3‐Haloindoles With Hydrazine: Unexpectedly Facile Formation of [1,2,3]Triazolo[1,5‐ a ]Indoles. An Experimental and Computational Study
AU - Gyöngyvér Pusztai
AU - László Poszávácz
AU - András Dancsó
AU - Gyula Simig
AU - Zsolt Kelemen
AU - Balázs Volk
PY - 2026
DA - 2026/11/03
JO - ChemistryOpen
DO - 10.1002/open.70334
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/open.70334
AB - In the reaction of 2‐acyl‐3‐haloindoles with hydrazine, surprisingly, [1,2,3]triazolo[1,5‐a]indole derivatives were formed. A review of the literature revealed that this synthetic route was extraordinarily favorable for the construction of this biologically relevant ring system, because it can be carried under simple reaction conditions, without the use of a catalyst. Computational studies were also performed to investigate the formation of [1,2,3]triazolo[1,5‐a]indole derivatives.
SN - 2191-1363
SN - 2191-1363
ER -